User profiles for Melissa Graewert
 | Melissa GraewertEMBL Hamburg Verified email at embl-hamburg.de Cited by 2544 |
[HTML][HTML] Versatile sample environments and automation for biological solution X-ray scattering experiments at the P12 beamline (PETRA III, DESY)
…, A Spilotros, F Schwemmer, MA Graewert… - Journal of applied …, 2015 - scripts.iucr.org
A high-brilliance synchrotron P12 beamline of the EMBL located at the PETRA III storage ring
(DESY, Hamburg) is dedicated to biological small-angle X-ray scattering (SAXS) and has …
(DESY, Hamburg) is dedicated to biological small-angle X-ray scattering (SAXS) and has …
[HTML][HTML] Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2
The coronavirus SARS-CoV-2 is the cause of the ongoing COVID-19 pandemic. Therapeutic
neutralizing antibodies constitute a key short-to-medium term approach to tackle COVID-19. …
neutralizing antibodies constitute a key short-to-medium term approach to tackle COVID-19. …
Impact and progress in small and wide angle X-ray scattering (SAXS and WAXS)
MA Graewert, DI Svergun - Current opinion in structural biology, 2013 - Elsevier
Highlights • Popularity of SAXS/WAXS for structural analysis has gained substantially. •
Remarkable developments in hardware and software allow for high-throughput studies. • SAXS …
Remarkable developments in hardware and software allow for high-throughput studies. • SAXS …
Preparing monodisperse macromolecular samples for successful biological small-angle X-ray and neutron-scattering experiments
Small-angle X-ray scattering (SAXS) and small-angle neutron scattering (SANS) are techniques
used to extract structural parameters and determine the overall structures and shapes of …
used to extract structural parameters and determine the overall structures and shapes of …
Limiting radiation damage for high-brilliance biological solution scattering: practical experience at the EMBL P12 beamline PETRAIII
CM Jeffries, MA Graewert, DI Svergun… - Journal of synchrotron …, 2015 - scripts.iucr.org
Radiation damage is the general curse of structural biologists who use synchrotron small-angle
X-ray scattering (SAXS) to investigate biological macromolecules in solution. The EMBL-…
X-ray scattering (SAXS) to investigate biological macromolecules in solution. The EMBL-…
[HTML][HTML] Automated pipeline for purification, biophysical and x-ray analysis of biomacromolecular solutions
Small angle X-ray scattering (SAXS), an increasingly popular method for structural analysis
of biological macromolecules in solution, is often hampered by inherent sample …
of biological macromolecules in solution, is often hampered by inherent sample …
[HTML][HTML] Adding size exclusion chromatography (SEC) and light scattering (LS) devices to obtain high-quality small angle X-ray scattering (SAXS) data
We describe the updated size-exclusion chromatography small angle X-ray scattering (SEC-SAXS)
set-up used at the P12 bioSAXS beam line of the European Molecular Biology …
set-up used at the P12 bioSAXS beam line of the European Molecular Biology …
[HTML][HTML] Quantitative size-resolved characterization of mRNA nanoparticles by in-line coupling of asymmetrical-flow field-flow fractionation with small angle X-ray …
MA Graewert, C Wilhelmy, T Bacic, J Schumacher… - Scientific reports, 2023 - nature.com
We present a generically applicable approach to determine an extensive set of size-dependent
critical quality attributes inside nanoparticulate pharmaceutical products. By coupling …
critical quality attributes inside nanoparticulate pharmaceutical products. By coupling …
EFAMIX, a tool to decompose inline chromatography SAXS data from partially overlapping components
PV Konarev, MA Graewert, CM Jeffries… - Protein …, 2022 - Wiley Online Library
Small‐angle X‐ray scattering (SAXS) is an established technique for structural analysis of
biological macromolecules in solution. During the last decade, inline chromatography setups …
biological macromolecules in solution. During the last decade, inline chromatography setups …
[HTML][HTML] LabDisk for SAXS: a centrifugal microfluidic sample preparation platform for small-angle X-ray scattering
…, D Kosse, S Zehnle, HDT Mertens, MA Graewert… - Lab on a Chip, 2016 - pubs.rsc.org
We present a centrifugal microfluidic LabDisk for protein structure analysis via small-angle X-ray
scattering (SAXS) on synchrotron beamlines. One LabDisk prepares 120 different …
scattering (SAXS) on synchrotron beamlines. One LabDisk prepares 120 different …