High lethality rates associated with metastatic cancer highlight an urgent medical need for
improved understanding of biologic mechanisms driving metastatic spread and identification …

Human beings contain complex societies of indigenous microbes, yet little is known about
how resident bacteria shape our physiology. We colonized germ-free mice with Bacteroides …

The tumor microenvironment (TME) consists of cells, soluble factors, signaling molecules,
extracellular matrix, and mechanical cues that can promote neoplastic transformation, support …

The enterohepatic circulation of bile acids is maintained by Na + -dependent transport
mechanisms. To better understand these processes, a full-length human ileal Na + -bile acid …

The canonical Wnt/β-catenin signalling pathway governs diverse developmental, homeostatic
and pathological processes. Palmitoylated Wnt ligands engage cell-surface frizzled (FZD) …

Active uptake of bile acids from the lumen of the small intestine is mediated by an ileal Na(+)-dependent
bile acid transport system. To identify components of this transport system, an …

Several cell populations have been reported to possess intestinal stem cell (ISC) activity
during homeostasis and injury-induced regeneration. Here, we explored inter-relationships …

Sodium-dependent bile acid transport in the rat ileum is abruptly expressed at weaning.
Degenerate oligonucleotides, based on amino acid sequence identities between the rat liver …

B cells foster squamous cell carcinoma (SCC) development through deposition of
immunoglobulin-containing immune complexes in premalignant tissue and Fcγ receptor-dependent …

During early embryogenesis, blood vessels and hematopoietic cells arise from a common
precursor cell, the hemangioblast. Recent studies have identified endothelial progenitor cells …