Dopamine supersensitivity correlates with D2High states, implying many paths to psychosis

…, BF O'dowd, SR George, ML Perreault… - Proceedings of the …, 2005 - National Acad Sciences
Dopamine supersensitivity occurs in schizophrenia and other psychoses, and after hippocampal
lesions, antipsychotics, ethanol, amphetamine, phencyclidine, gene knockouts of Dbh (…

Psychosis pathways converge via D2High dopamine receptors

…, J Schwarz, JF Chen, H Szechtman, M Perreault… - Synapse, 2006 - Wiley Online Library
The objective of this review is to identify a target or biomarker of altered neurochemical
sensitivity that is common to the many animal models of human psychoses associated with street …

Transient dose-dependent effects of ketamine on neural oscillatory activity in Wistar-Kyoto rats

…, OOF Williams, DJ Rasmussen, ML Perreault - Neuroscience, 2020 - Elsevier
Ketamine is a promising therapeutic for treatment-resistant depression (TRD) but is associated
with an array of short-term psychomimetic side-effects. These disparate drug effects may …

Calcium signaling cascade links dopamine D1–D2 receptor heteromer to striatal BDNF production and neuronal growth

…, T Nguyen, ML Perreault… - Proceedings of the …, 2009 - National Acad Sciences
Although the perturbation of either the dopaminergic system or brain-derived neurotrophic
factor (BDNF) levels has been linked to important neurological and neuropsychiatric disorders…

[HTML][HTML] The dopamine D1-D2 receptor heteromer localizes in dynorphin/enkephalin neurons: increased high affinity state following amphetamine and in …

ML Perreault, A Hasbi, M Alijaniaram, T Fan… - Journal of Biological …, 2010 - ASBMB
The distribution and function of neurons coexpressing the dopamine D1 and D2 receptors
in the basal ganglia and mesolimbic system are unknown. We found a subset of medium …

[HTML][HTML] Heteromeric dopamine receptor signaling complexes: emerging neurobiology and disease relevance

ML Perreault, A Hasbi, BF O'dowd… - …, 2014 - nature.com
The pharmacological modification of dopamine transmission has long been employed as a
therapeutic tool in the treatment of many mental health disorders. However, as many of the …

[HTML][HTML] The dopamine D1–D2 receptor heteromer in striatal medium spiny neurons: evidence for a third distinct neuronal pathway in basal ganglia

ML Perreault, A Hasbi, BF O'Dowd… - Frontiers in …, 2011 - frontiersin.org
Dopaminergic signaling within the basal ganglia has classically been thought to occur
within two distinct neuronal pathways; the direct striatonigral pathway which contains the …

[HTML][HTML] Sex differences in dopamine receptors and relevance to neuropsychiatric disorders

OOF Williams, M Coppolino, SR George, ML Perreault - Brain sciences, 2021 - mdpi.com
Dopamine is an important neurotransmitter that plays a key role in neuropsychiatric illness.
Sex differences in dopaminergic signaling have been acknowledged for decades and have …

[HTML][HTML] Sex difference in dopamine D1-D2 receptor complex expression and signaling affects depression-and anxiety-like behaviors

…, S Miksys, RF Tyndale, BK Madras, ML Perreault… - Biology of sex …, 2020 - Springer
Depression and anxiety are more common among females than males and represent a
leading cause of disease-related disability in women. Since the dopamine D1-D2 heteromer is …

[HTML][HTML] Bipolar disorder-iPSC derived neural progenitor cells exhibit dysregulation of store-operated Ca2+ entry and accelerated differentiation

…, J Wang, N Becke, E Chartley, M Perreault… - Molecular …, 2023 - nature.com
While most of the efforts to uncover mechanisms contributing to bipolar disorder (BD) focused
on phenotypes at the mature neuron stage, little research has considered events that may …