Cell death can be executed by regulated apoptotic and nonapoptotic pathways, including the
iron-dependent process of ferroptosis. Small molecules are essential tools for studying the …

Iridoviridae, such as the lymphocystis disease virus-1 (LCDV-1) and other viruses, encode
viral insulin–like peptides (VILPs) which are capable of triggering insulin receptors (IRs) and …

Lipid peroxidation (LPO) is associated with a variety of pathologies and drives a form of
regulated necrosis called ferroptosis. There is much interest in small-molecule inhibitors of LPO …

Cell death can be executed by regulated apoptotic and non-apoptotic pathways, including the
iron-dependent process of ferroptosis. Small molecules are essential tools for studying the …

Acute kidney tubular necrosis (ATN) mediates acute kidney injury (AKI) and nephron loss,
the major risk factor for chronic kidney disease (CKD) progression and end-stage renal …

Nitroxides are intermediates in the accepted reaction mechanisms of the antioxidant activity
of diarylamines and hindered alkyl amines. The parent amines are used as additives to …

Lipid peroxidation is believed to play a key role in the onset and progression of degenerative
disease. Interestingly, although cholesterol is the most abundant lipid in the human body, …

Radical mediated autoxidation is a pervasive phenomenon in commercial (ie rubbers, fuels,
lubricants, etc.) and biological contexts (ie lipid peroxidation associated with …

Autoxidation, a radical chain reaction, is largely responsible for the degradation of most man-made
and biological materials. These include chemical products such as lubricants, …

Plasmalogens have been reported to possess antioxidant activity; a paradoxical finding given
that plasmalogens often comprise highly oxidizable polyunsaturated fatty acids esterified …