Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide
association study (GWAS) including 20,352 cases and 31,358 controls of European descent, …

Several families with an early–onset form of familial Alzheimer's disease have been found to
harbour mutations at a specific codon (717) of the gene for the β–amyloid precursor protein (…

Alpha-2-macroglobulin (α-2 M; encoded by the gene A2M) is a serum pan-protease inhibitor
that has been implicated in Alzheimer disease (AD) based on its ability to mediate the …

With the proliferation of multi-site neuroimaging studies, there is a greater need for handling
non-biological variance introduced by differences in MRI scanners and acquisition protocols…

Recent studies suggest that insulin-degrading enzyme (IDE) in neurons and microglia degrades
Aβ, the principal component of β-amyloid and one of the neuropathological hallmarks of …

Several psychiatric disorders — such as bipolar disorder, schizophrenia and autism — are
highly heritable, yet identifying their genetic basis has been challenging, with most …

The genetic aetiologies of at least 20% of autosomal dominant spinocerebellar ataxias (SCAs)
have yet to be elucidated 1. We have recently identified a novel form of autosomal …

Genome scans of bipolar disorder (BPD) have not produced consistent evidence for linkage.
The rank-based genome scan meta-analysis (GSMA) method was applied to 18 BPD …

To identify bipolar disorder (BD) genetic susceptibility factors, we conducted two genome-wide
association (GWA) studies: one involving a sample of individuals of European ancestry (…

Alzheimer's disease (AD) is a devastating neurodegenerative disorder of late life with
complex inheritance. Mutations in three known genes lead to the rare early-onset autosomal …