Alternative splicing allows expression of mRNA isoforms from a single gene, expanding the
diversity of the proteome. Its prevalence in normal biological and disease processes warrant …

Here we develop a methylation editing toolbox, Casilio-ME, that enables not only RNA-guided
methylcytosine editing by targeting TET1 to genomic sites, but also by co-delivering TET1 …

Non-small cell lung cancer (NSCLC) accounts for 80–85% of all lung cancer which is the
leading cause of cancer death worldwide. Eighty percent of NSCLC patients exhibit high levels …

Three-dimensional (3D) structures of the genome are dynamic, heterogeneous and functionally
important. Live cell imaging has become the leading method for chromatin dynamics …

Heart aging is a prevalent cause of cardiovascular diseases among the elderly. NAD +
depletion is a hallmark feature of aging heart, however, the molecular mechanisms that affect …

Selectable markers are widely used in transgenesis and genome editing for selecting
engineered cells with a desired genotype but the variety of markers is limited. Here we present …

Lung adenocarcinoma (LUAD) is a prevalent type of thoracic cancer with a poor prognosis
and high mortality rate. However, the exact pathogenesis of this cancer is still not fully …

… Menghan Du: conducted the staining experiments. Pingping Tang: conducted western
blot and qRT-PCR experiments. Yongchao Chen: conducted western blot and qRT-PCR …

Background The quality of traditional Chinese medicines (TCMs) directly impacts their clinical
efficacy and drug safety, making standardization a critical component of modern TCMs. …

Diabetic cardiomyopathy (DCM) is widely recognized as a major contributing factor to the
development of heart failure in patients with diabetes. Previous studies have demonstrated the …