Immune-checkpoint blockade (ICB) has demonstrated efficacy in many tumor types, but
predictors of responsiveness to anti-PD1 ICB are incompletely characterized. In this study, we …

Metastatic castration-resistant prostate cancer is typically lethal, exhibiting intrinsic or acquired
resistance to second-generation androgen-targeting therapies and minimal response to …

Immune checkpoint blockade (ICB) results in durable disease control in a subset of patients
with advanced renal cell carcinoma (RCC), but mechanisms driving resistance are poorly …

Defining the transition from benign to malignant tissue is fundamental to improving early
diagnosis of cancer 1 . Here we use a systematic approach to study spatial genome integrity in …

The immune composition of the tumor microenvironment influences response and resistance
to immunotherapies. While numerous studies have identified somatic correlates of immune …

Ex vivo systems that incorporate features of the tumor microenvironment and model the
dynamic response to immune checkpoint blockade (ICB) may facilitate efforts in precision …

Capture array-based spatial transcriptomics methods have been widely used to resolve gene
expression in tissues; however, their spatial resolution is limited by the density of the array. …

We present an in silico approach to identifying neoepitopes derived from intron retention events
in tumor transcriptomes. Using mass spectrometry immunopeptidome analysis, we show …

Parental care is essential for the survival of mammals, yet the mechanisms underlying its
evolution remain largely unknown. Here we show that two sister species of mice, Peromyscus …

Precursor states of multiple myeloma (MM) and its native tumor microenvironment need in-depth
molecular characterization to better stratify and treat patients at risk. Using single-cell …