A review of biosensor technologies for blood biomarkers toward monitoring cardiovascular diseases at the point-of-care

M Ouyang, D Tu, L Tong, M Sarwar, A Bhimaraj… - Biosensors and …, 2021 - Elsevier
Cardiovascular diseases (CVDs) cause significant mortality globally. Notably, CVDs
disproportionately negatively impact underserved populations, such as those that are economically …

Amphiphilic Particle-Stabilized Nanoliter Droplet Reactors with a Multimodal Portable Reader for Distributive Biomarker Quantification

…, A Arnheim, S Udani, D Tseng, Y Luo, M Ouyang… - ACS …, 2023 - ACS Publications
Compartmentalization, leveraging microfluidics, enables highly sensitive assays, but the
requirement for significant infrastructure for their design, build, and operation limits access. …

Fabrication of 3D concentric amphiphilic microparticles to form uniform nanoliter reaction volumes for amplified affinity assays

G Destgeer, M Ouyang, CY Wu, D Di Carlo - Lab on a Chip, 2020 - pubs.rsc.org
Reactions performed in uniform microscale volumes have enabled numerous applications
in the analysis of rare entities (eg cells and molecules). Here, highly monodisperse aqueous …

Monodisperse drops templated by 3D-structured microparticles

CY Wu, M Ouyang, B Wang, J de Rutte, A Joo… - Science …, 2020 - science.org
The ability to create uniform subnanoliter compartments using microfluidic control has
enabled new approaches for analysis of single cells and molecules. However, specialized …

[HTML][HTML] Computational cytometer based on magnetically modulated coherent imaging and deep learning

Y Zhang, M Ouyang, A Ray, T Liu, J Kong… - Light: Science & …, 2019 - nature.com
Detecting rare cells within blood has numerous applications in disease diagnostics. Existing
rare cell detection techniques are typically hindered by their high cost and low throughput. …

Engineering design of concentric amphiphilic microparticles for spontaneous formation of picoliter to nanoliter droplet volumes

G Destgeer, M Ouyang, D Di Carlo - Analytical Chemistry, 2021 - ACS Publications
Simple mixing of aqueous and oil solutions with amphiphilic particles leads to the spontaneous
formation of uniform reaction volumes (dropicles) that can enable numerous applications …

Nanoplasmonic swarm biosensing using single nanoparticle colorimetry

M Ouyang, D Di Carlo - Biosensors and Bioelectronics, 2019 - Elsevier
We demonstrate a swarm biosensing platform that detects analyte based on the change in
plasmonic signal from thousands of single nanoparticles sensors, leading to increased …

An AC electrokinetics facilitated biosensor cassette for rapid pathogen identification

M Ouyang, R Mohan, Y Lu, T Liu, KE Mach, MLY Sin… - Analyst, 2013 - pubs.rsc.org
To develop a portable point-of-care system based on biosensors for common infectious
diseases such as urinary tract infection, the sensing process needs to be implemented within an …

[HTML][HTML] Sensitizing drug-resistant cancer cells from blood using microfluidic electroporator

HW Sung, SE Choi, CH Chu, M Ouyang, S Kalyan… - PloS one, 2022 - journals.plos.org
Direct assessment of patient samples holds unprecedented potential in the treatment of cancer.
Circulating tumor cells (CTCs) in liquid biopsies are a rapidly evolving source of primary …

[HTML][HTML] Microscale symmetrical electroporator array as a versatile molecular delivery system

M Ouyang, W Hill, JH Lee, SC Hur - Scientific reports, 2017 - nature.com
Successful developments of new therapeutic strategies often rely on the ability to deliver
exogenous molecules into cytosol. We have developed a versatile on-chip vortex-assisted …