The central nervous system has historically been viewed as an immune-privileged site, but
recent data have shown that the meninges—the membranes that surround the brain and …

Abstract Analysis of human blood immune cells provides insights into the coordinated
response to viral infections such as severe acute respiratory syndrome coronavirus 2, which …

The cellular landscape of the human intestinal tract is dynamic throughout life, developing
in utero and changing in response to functional requirements and environmental exposures. …

Single-cell genomics studies have decoded the immune cell composition of several human
prenatal organs but were limited in describing the developing immune system as a …

NLRP3 is a key component of the macromolecular signaling complex called the inflammasome
that promotes caspase 1-dependent production of IL-1β. The adaptor ASC is necessary …

FcγRIIB is the only inhibitory Fc receptor. It controls many aspects of immune and inflammatory
responses, and variation in the gene encoding this protein has long been associated with …

It is not fully understood why COVID-19 is typically milder in children 1 , 2 – 3 . Here, to examine
the differences between children and adults in their response to SARS-CoV-2 infection, …

INTRODUCTION The thymus is the critical organ for T cell development and T cell receptor (TCR)
repertoire formation, which shapes the landscape of adaptive immunity. T cell …

Dysfunction of receptors for IgG (FcγRs) has been thought to be involved in the pathogenesis
of systemic lupus erythematosus (SLE). We show that a recently described SLE-associated …

Single-cell transcriptomics has allowed unprecedented resolution of cell types/states in the
human lung, but their spatial context is less well defined. To (re)define tissue architecture of …