Blind prediction of homo‐and hetero‐protein complexes: The CASP13‐CAPRI experiment

…, T Park, H Woo, C Seok, M Braitbard… - Proteins: Structure …, 2019 - Wiley Online Library
We present the results for CAPRI Round 46, the third joint CASP‐CAPRI protein assembly
prediction challenge. The Round comprised a total of 20 targets including 14 homo‐oligomers …

Targeted in situ cross-linking mass spectrometry and integrative modeling reveal the architectures of three proteins from SARS-CoV-2

…, K Zohar, T Eliyahu, M Braitbard… - Proceedings of the …, 2021 - National Acad Sciences
Atomic structures of several proteins from the coronavirus family are still partial or unavailable.
A possible reason for this gap is the instability of these proteins outside of the cellular …

[PDF][PDF] Structure of the human core centromeric nucleosome complex

…, T Van Eeuwen, M Slavin, M Braitbard… - Current Biology, 2019 - cell.com
Centromeric nucleosomes are at the interface of the chromosome and the kinetochore that
connects to spindle microtubules in mitosis. The core centromeric nucleosome complex (…

Integrative structure modeling: overview and assessment

M Braitbard, D Schneidman-Duhovny… - Annual review of …, 2019 - annualreviews.org
Integrative structure modeling computationally combines data from multiple sources of
information with the aim of obtaining structural insights that are not revealed by any single …

[HTML][HTML] Cryo-EM structures of engineered active bc1-cbb3 type CIII2CIV super-complexes and electronic communication between the complexes

…, T van Eeuwen, Y Ozturk, HJ Kim, M Braitbard… - Nature …, 2021 - nature.com
Respiratory electron transport complexes are organized as individual entities or combined
as large supercomplexes (SC). Gram-negative bacteria deploy a mitochondrial-like …

The Cdc48 N-terminal domain has a molecular switch that mediates the Npl4-Ufd1-Cdc48 complex formation

T Oppenheim, M Radzinski, M Braitbard, ES Brielle… - Structure, 2023 - cell.com
Cdc48 (VCP/p97) is a major AAA-ATPase involved in protein quality control, along with its
canonical cofactors Ufd1 and Npl4 (UN). Here, we present novel structural insights into the …

Dynamic Evolution of the Cthrc1 Genes, a Newly Defined Collagen-Like Family

…, TS Nir, M Bazarsky, M Braitbard… - Genome Biology and …, 2020 - academic.oup.com
Collagen triple helix repeat containing protein 1 (Cthrc1) is a secreted glycoprotein reported
to regulate collagen deposition and to be linked to the Transforming growth factor β/Bone …

Cryo-EM Structures of Respiratory bc1-cbb3 type CIII2CIV Supercomplex and Electronic Communication Between the Complexes

…, T VanEeuwen, Y Ozturk, HJ Kim, M Braitbard… - bioRxiv, 2020 - biorxiv.org
The respiratory electron transport complexes convey electrons from nutrients to oxygen and
generate a proton-motive force used for energy (ATP) production in cells. These enzymes …

The structural basis for the self-inhibition of DNA binding by apo-σ70

K Joron, J Zamel, S Dvir, N Kalisman, E Lerner - bioRxiv, 2022 - biorxiv.org
… Dina Schneidman and Merav Braitbard for providing PatchDock and assisting in the docking
procedures, (ii) Dr. Paul David Harris for consultation regarding mpH 2 MM analyses of …

[HTML][HTML] Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes

S Tremel, Y Ohashi, DR Morado, J Bertram… - Nature …, 2021 - nature.com
The lipid phosphatidylinositol-3-phosphate (PI3P) is a regulator of two fundamental but
distinct cellular processes, endocytosis and autophagy, so its generation needs to be under …