User profiles for Merav Socolovsky
merav socolovskyUniversity of Massachusetts Medical School Verified email at umassmed.edu Cited by 6451 |
Global DNA demethylation during mouse erythropoiesis in vivo
In the mammalian genome, 5′-CpG-3′ dinucleotides are frequently methylated, correlating
with transcriptional silencing. Genome-wide demethylation is thought to occur only twice …
with transcriptional silencing. Genome-wide demethylation is thought to occur only twice …
Population snapshots predict early haematopoietic and erythroid hierarchies
The formation of red blood cells begins with the differentiation of multipotent haematopoietic
progenitors. Reconstructing the steps of this differentiation represents a general challenge …
progenitors. Reconstructing the steps of this differentiation represents a general challenge …
Identification and analysis of mouse erythroid progenitors using the CD71/TER119 flow-cytometric assay
The study of erythropoiesis aims to understand how red cells are formed from earlier
hematopoietic and erythroid progenitors. Specifically, the rate of red cell formation is regulated by …
hematopoietic and erythroid progenitors. Specifically, the rate of red cell formation is regulated by …
Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo
Erythropoietin (Epo) is the principal regulator of the erythropoietic response to hypoxic stress,
through its receptor, EpoR. The EpoR signals mediating the stress response are largely …
through its receptor, EpoR. The EpoR signals mediating the stress response are largely …
[HTML][HTML] Fetal anemia and apoptosis of red cell progenitors in Stat5a−/− 5b−/− mice: a direct role for Stat5 in Bcl-XL induction
M Socolovsky, AEJ Fallon, S Wang, C Brugnara… - Cell, 1999 - cell.com
The erythropoietin receptor (EpoR) is essential for production of red blood cells; a principal
function of EpoR is to rescue committed erythroid progenitors from apoptosis. Stat5 is rapidly …
function of EpoR is to rescue committed erythroid progenitors from apoptosis. Stat5 is rapidly …
Ineffective erythropoiesis in Stat5a−/−5b−/− mice due to decreased survival of early erythroblasts
M Socolovsky, H Nam, MD Fleming… - Blood, The Journal …, 2001 - ashpublications.org
Erythropoietin (Epo) controls red cell production in the basal state and during stress. Epo
binding to its receptor, EpoR, on erythroid progenitors leads to rapid activation of the …
binding to its receptor, EpoR, on erythroid progenitors leads to rapid activation of the …
Vascular tumors in livers with targeted inactivation of the von Hippel–Lindau tumor suppressor
…, JN Glickman, M Socolovsky… - Proceedings of the …, 2001 - National Acad Sciences
von Hippel–Lindau (VHL) disease is a pleomorphic familial tumor syndrome that is characterized
by the development of highly vascularized tumors. Homozygous disruption of the VHL …
by the development of highly vascularized tumors. Homozygous disruption of the VHL …
Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: functional analysis by a flow cytometry–based novel culture system
J Zhang, M Socolovsky, AW Gross, HF Lodish - Blood, 2003 - ashpublications.org
Ras signaling plays an important role in erythropoiesis. Its function has been extensively
studied in erythroid and nonerythroid cell lines as well as in primary erythroblasts, but …
studied in erythroid and nonerythroid cell lines as well as in primary erythroblasts, but …
[PDF][PDF] Genetic analysis of BRCA1 function in a defined tumor cell line
…, S Ganesan, K Vlasakova, J Chen, M Socolovsky… - Molecular cell, 1999 - cell.com
Retrovirally expressed, wild-type BRCA1 decreased the γ radiation (IR) sensitivity and
increased the efficiency of double-strand DNA break repair (DSBR) of the BRCA1 −/− human …
increased the efficiency of double-strand DNA break repair (DSBR) of the BRCA1 −/− human …
Fundamental limits on dynamic inference from single-cell snapshots
Single-cell expression profiling reveals the molecular states of individual cells with unprecedented
detail. Because these methods destroy cells in the process of analysis, they cannot …
detail. Because these methods destroy cells in the process of analysis, they cannot …