User profiles for Merav Socolovsky

merav socolovsky

University of Massachusetts Medical School
Verified email at umassmed.edu
Cited by 6451

Global DNA demethylation during mouse erythropoiesis in vivo

…, R Pop, C Bock, P Boyle, A Meissner, M Socolovsky - Science, 2011 - science.org
In the mammalian genome, 5′-CpG-3′ dinucleotides are frequently methylated, correlating
with transcriptional silencing. Genome-wide demethylation is thought to occur only twice …

Population snapshots predict early haematopoietic and erythroid hierarchies

…, A Waisman, JR Huh, AM Klein, M Socolovsky - Nature, 2018 - nature.com
The formation of red blood cells begins with the differentiation of multipotent haematopoietic
progenitors. Reconstructing the steps of this differentiation represents a general challenge …

Identification and analysis of mouse erythroid progenitors using the CD71/TER119 flow-cytometric assay

…, JR Shearstone, D Hidalgo, M Socolovsky - JoVE (Journal of …, 2011 - jove.com
The study of erythropoiesis aims to understand how red cells are formed from earlier
hematopoietic and erythroid progenitors. Specifically, the rate of red cell formation is regulated by …

Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo

…, C Sadegh, C Brugnara, VH Haase, M Socolovsky - Blood, 2006 - ashpublications.org
Erythropoietin (Epo) is the principal regulator of the erythropoietic response to hypoxic stress,
through its receptor, EpoR. The EpoR signals mediating the stress response are largely …

[HTML][HTML] Fetal anemia and apoptosis of red cell progenitors in Stat5a−/− 5b−/− mice: a direct role for Stat5 in Bcl-XL induction

M Socolovsky, AEJ Fallon, S Wang, C Brugnara… - Cell, 1999 - cell.com
The erythropoietin receptor (EpoR) is essential for production of red blood cells; a principal
function of EpoR is to rescue committed erythroid progenitors from apoptosis. Stat5 is rapidly …

Ineffective erythropoiesis in Stat5a−/−5b−/− mice due to decreased survival of early erythroblasts

M Socolovsky, H Nam, MD Fleming… - Blood, The Journal …, 2001 - ashpublications.org
Erythropoietin (Epo) controls red cell production in the basal state and during stress. Epo
binding to its receptor, EpoR, on erythroid progenitors leads to rapid activation of the …

Vascular tumors in livers with targeted inactivation of the von Hippel–Lindau tumor suppressor

…, JN Glickman, M Socolovsky… - Proceedings of the …, 2001 - National Acad Sciences
von Hippel–Lindau (VHL) disease is a pleomorphic familial tumor syndrome that is characterized
by the development of highly vascularized tumors. Homozygous disruption of the VHL …

Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: functional analysis by a flow cytometry–based novel culture system

J Zhang, M Socolovsky, AW Gross, HF Lodish - Blood, 2003 - ashpublications.org
Ras signaling plays an important role in erythropoiesis. Its function has been extensively
studied in erythroid and nonerythroid cell lines as well as in primary erythroblasts, but …

[PDF][PDF] Genetic analysis of BRCA1 function in a defined tumor cell line

…, S Ganesan, K Vlasakova, J Chen, M Socolovsky… - Molecular cell, 1999 - cell.com
Retrovirally expressed, wild-type BRCA1 decreased the γ radiation (IR) sensitivity and
increased the efficiency of double-strand DNA break repair (DSBR) of the BRCA1 −/− human …

Fundamental limits on dynamic inference from single-cell snapshots

…, S Wolock, BK Tusi, M Socolovsky… - Proceedings of the …, 2018 - National Acad Sciences
Single-cell expression profiling reveals the molecular states of individual cells with unprecedented
detail. Because these methods destroy cells in the process of analysis, they cannot …