Background— Dicer, an RNAse III endonuclease critical for processing of pre-microRNAs (miRNAs)
into mature 22-nucleotide miRNAs, has proven a useful target to dissect the …

Peroxisome proliferator-activated receptor δ (PPARδ) is a critical regulator of energy
metabolism in the heart. Here, we propose a mechanism that integrates two deleterious …

One major intracellular signaling pathway involved in heart failure employs the phosphatase
calcineurin and its downstream transcriptional effector nuclear factor of activated T-cells (…

Although aberrant reactivation of embryonic gene programs is intricately linked to
pathological heart disease, the transcription factors driving these gene programs remain ill-defined. …

Background— Hypertrophic growth, a risk factor for mortality in heart disease, is driven by
reprogramming of cardiac gene expression. Although the transcription factor myocyte …

Tumor-angiogenesis is the multi-factorial process of sprouting of endothelial cells (EC) into
micro-vessels to provide tumor cells with nutrients and oxygen. To explore miRNAs as …

Calcineurin/NFAT signaling is involved in multiple aspects of skeletal muscle development
and disease. The myogenic basic helix-loop-helix transcription factors, MyoD, myogenin, Myf5…

BipotentR presents resources for evaluating patient response and identifying targets for
drugs that can kill tumors through multiple mechanisms concurrently. Inhibition of the topmost …

The aim of the present study was to improve the immunogenicity of peptide epitope
vaccines using novel nanocarriers based on self-assembling materials. Several studies …

Selective elimination of macrophages by photodynamic therapy (PDT) is a new and
promising therapeutic modality for the reduction of atherosclerotic plaques. m-Tetra(hydroxyphenyl)…