Alzheimer's disease (AD) is the most common form of dementia and it is characterized by the
deposition of amyloid-β (Aβ) plaques and neurofibrillary tangles in the brain. However, the …

Temporal lobe epilepsy is a common, chronic neurological disorder characterized by recurrent
spontaneous seizures. MicroRNAs (miRNAs) are small, noncoding RNAs that regulate …

The dendritic spines on pyramidal cells represent the main postsynaptic elements of cortical
excitatory synapses and they are fundamental structures in memory, learning and cognition. …

Emerging data support roles for microRNA (miRNA) in the pathogenesis of various
neurologic disorders including epilepsy. MicroRNA-134 (miR-134) is enriched in dendrites of …

Insulin signalling deficiencies and insulin resistance have been directly linked to the
progression of neurodegenerative disorders like Alzheimer’s disease. However, to date little is …

Inflammation plays an important role in Alzheimer’s disease (AD) and other neurodegenerative
disorders. Although chronic inflammation in later stages of AD is well described, little is …

Hypercholesterolemia is associated with cognitively deteriorated states. Here, we show that
excess 27-hydroxycholesterol (27-OH), a cholesterol metabolite passing from the circulation …

The lifetime of proteins in synapses is important for their signaling, maintenance, and
remodeling, and for memory duration. We quantified the lifetime of endogenous PSD95, an …

Hypercholesterolemia is a risk factor for neurodegenerative diseases, but how high blood
cholesterol levels are linked to neurodegeneration is still unknown. Here, we show that an …

Several studies support the relation between leptin and Alzheimer's disease ( AD ). We
show that leptin levels in CSF are unchanged as subjects progress to AD . However, in AD …