Alzheimer's disease is a form of localized amyloidosis characterized by cerebral cortical
amyloid plaques, neurofibrillary tangles, and amyloid deposits within the walls of …

Background Hereditary transthyretin amyloidosis is caused by pathogenic single-nucleotide
variants in the gene encoding transthyretin (TTR) that induce transthyretin misfolding and …

Full article: Amyloid fibril proteins and amyloidosis: chemical identification and clinical
classification International Society of Amyloidosis 2016 Nomenclature Guidelines Skip to Main …

Background When the chemical diversity of amyloid and amyloidosis became apparent in the
mid-1970s, participants in the International Symposium on Amyloidosis, Helsinki, Finland, …

The nomenclature committee of the International Society of Amyloidosis (ISA) meets every
second year to discuss and formulate recommendations. The conclusions from the discussion …

The ISA Nomenclature Committee met electronically before and directly after the XVII ISA
International Symposium on Amyloidosis, which, unfortunately, had to be virtual in September …

Neuropathy is often a major manifestation of systemic amyloidosis. It is most frequently seen
in patients with hereditary transthyretin (TTR) amyloidosis, but is also present in 20% of …

A system of amyloid fibril nomenclature based on the chemical identity of the amyloid fibril
forming protein is recommended. This system has been in use for approximately 40 years, but …

Tissue deposition of normally soluble proteins, or their fragments, as insoluble amyloid fibrils
causes the usually fatal, acquired and hereditary systemic amyloidoses and is associated …

The increasing knowledge of the exact biochemical nature of the localized and systemic
amyloid disorders has made a logical and easily understood nomenclature absolutely …