Lysosomal membrane permeabilization and subsequent cell death may prove useful in
cancer treatment, provided that cancer cell lysosomes can be specifically targeted. Here, we …

In yeast, a protein complex termed the ER ‐Mitochondria Encounter Structure ( ERMES )
tethers mitochondria to the endoplasmic reticulum. ERMES proteins are implicated in a variety …

Hedgehog ligands control tissue development and homeostasis by alleviating repression of
Smoothened, a seven-pass transmembrane protein. The Hedgehog receptor, Patched, is …

Acid ceramidase (AC) is a lysosomal hydrolase encoded by the ASAH1 gene, which cleaves
ceramides into sphingosine and fatty acid. AC is expressed at high levels in most human …

Sphingolipids are a diverse group of lipids with important roles in beta-cell biology regulating
insulin folding and controlling apoptosis. Sphingolipid biosynthesis begins with the …

Cancer cells are dependent on cholesterol, and they possess strictly controlled cholesterol
homeostasis mechanisms. These allow them to smoothly switch between cholesterol …

Squalene synthase (SQS) is an essential enzyme in the mevalonate pathway, which controls
cholesterol biosynthesis and homeostasis. Although catalytic inhibitors of SQS have been …

Introduction Repurposing of cationic amphiphilic drugs (CADs) emerges as an attractive
therapeutic solution against various cancers, including leukemia. CADs target lysosomal lipid …

Shotgun lipidomics is a powerful tool that enables simultaneous and fast quantification of
diverse lipid classes through mass spectrometry based analyses of directly infused crude lipid …

PCSK9 induces lysosomal degradation of the low-density lipoprotein (LDL) receptor (LDLR)
in the liver, hereby preventing removal of LDL cholesterol from the circulation. Accordingly, …