FlyFactorSurvey (http://pgfe.umassmed.edu/TFDBS/) is a database of DNA binding specificities
for Drosophila transcription factors (TFs) primarily determined using the bacterial one-…

Cys 2 -His 2 zinc finger proteins (ZFPs) are the largest family of transcription factors in higher
metazoans. They also represent the most diverse family with regards to the composition of …

Recent advances in single-cell techniques catalyze an emerging field of studying how cells
convert from one phenotype to another, in a step-by-step process. Two grand technical …

Cys 2 -His 2 zinc finger proteins (ZFPs) are the largest group of transcription factors in
higher metazoans. A complete characterization of these ZFPs and their associated target …

Motivation: Recognition models for protein-DNA interactions, which allow the prediction of
specificity for a DNA-binding domain based only on its sequence or the alteration of specificity …

A recent model for the mechanism of intrinsic transcription termination involves dissociation
of the RNA from forward-translocated (hypertranslocated) states of the complex [Yarnell WS, …

Recent advances in single cell techniques catalyze an emerging field of studying how cells
convert from one phenotype to another, in a step-by-step process. Two grand technical …

Melanoma remains the most lethal form of skin cancer exhibiting high mortality rates due to
a high likelihood of developing metastases and acquiring drug resistance. Approximately 40-…

During transcription initiation, competition between the initiation and elongation processes
is thought to lead to the production of abortive transcripts (2–8 nucleotides of RNA) by the …

Mutant BRAF gene can lead to uncontrolled cell growth through overactivation of RAS-RAF-MAPK
signaling pathway. BRAF V600E mutation occurs in approximately 40% to 50% of …