Pfam is a large collection of protein families and domains. Over the past 2 years the number
of families in Pfam has doubled and now stands at 6190 (version 10.0). Methodology …

A central aim of cancer research has been to identify the mutated genes that are causally
implicated in oncogenesis ('cancer genes'). After two decades of searching, how many have …

Pfam is a large collection of protein multiple sequence alignments and profile hidden
Markov models. Pfam is available on the World Wide Web in the UK at http://www.sanger.ac.uk/…

Pfam is a database of protein families that currently contains 7973 entries (release 18.0). A
recent development in Pfam has enabled the grouping of related families into clans. Pfam …

MicroRNAs (miRNAs) are small noncoding RNA gene products about 22 nt long that are
processed by Dicer from precursors with a characteristic hairpin secondary structure. …

Rfam is a collection of multiple sequence alignments and covariance models representing
non-coding RNA families. Rfam is available on the web in the UK at http://www.sanger.ac.uk/…

Rfam is a comprehensive collection of non-coding RNA (ncRNA) families, represented by
multiple sequence alignments and profile stochastic context-free grammars. Rfam aims to …

The extent to which low‐frequency (minor allele frequency (MAF) between 1–5%) and rare (MAF
≤ 1%) variants contribute to complex traits and disease in the general population is …

Objective Ankylosing spondylitis (AS) is a common, highly heritable immune‐mediated
arthropathy that occurs in genetically susceptible individuals exposed to an unknown but likely …

There are many resources that contain information about binary interactions between proteins.
However, protein interactions are defined by only a subset of residues in any protein. We …