[HTML][HTML] Intrahepatic microbes govern liver immunity by programming NKT cells
…, G Werba, S Pushalkar, M McKinstry… - The Journal of …, 2022 - Am Soc Clin Investig
The gut microbiome shapes local and systemic immunity. The liver is presumed to be a protected
sterile site. As such, a hepatic microbiome has not been examined. Here, we showed a …
sterile site. As such, a hepatic microbiome has not been examined. Here, we showed a …
[PDF][PDF] Definitive hematopoietic stem cells minimally contribute to embryonic hematopoiesis
BA Ulloa, SS Habbsa, KS Potts, A Lewis, M McKinstry… - Cell reports, 2021 - cell.com
Hematopoietic stem cells (HSCs) are rare cells that arise in the embryo and sustain adult
hematopoiesis. Although the functional potential of nascent HSCs is detectable by …
hematopoiesis. Although the functional potential of nascent HSCs is detectable by …
[HTML][HTML] The heat shock response and humoral immune response are mutually antagonistic in honey bees
M McKinstry, C Chung, H Truong, BA Johnston… - Scientific Reports, 2017 - nature.com
The honey bee is of paramount importance to humans in both agricultural and ecological
settings. Honey bee colonies have suffered from increased attrition in recent years, stemming …
settings. Honey bee colonies have suffered from increased attrition in recent years, stemming …
[PDF][PDF] Splicing factor deficits render hematopoietic stem and progenitor cells sensitive to STAT3 inhibition
Hematopoietic stem and progenitor cells (HSPCs) sustain lifelong hematopoiesis. Mutations
of pre-mRNA splicing machinery, especially splicing factor 3b, subunit 1 (SF3B1), are early …
of pre-mRNA splicing machinery, especially splicing factor 3b, subunit 1 (SF3B1), are early …
Divergent forms of endoplasmic reticulum stress trigger a robust unfolded protein response in honey bees
BA Johnston, KB Hooks, M McKinstry… - Journal of insect …, 2016 - Elsevier
Honey bee colonies in the United States have suffered from an increased rate of die-off in
recent years, stemming from a complex set of interacting stresses that remain poorly described…
recent years, stemming from a complex set of interacting stresses that remain poorly described…
Robust transcriptional response to heat shock impacting diverse cellular processes despite lack of heat shock factor in microsporidia
NK McNamara-Bordewick, M McKinstry, JW Snow - Msphere, 2019 - Am Soc Microbiol
The majority of fungal species prefer the 12 to 30C range, and relatively few species tolerate
temperatures higher than 35C. Our understanding of the mechanisms underpinning the …
temperatures higher than 35C. Our understanding of the mechanisms underpinning the …
[HTML][HTML] Retained metabolic activity in honey bee collected pollen has implications for pollen digestion and effects on honey bee health
M McKinstry, SR Prado-Irwin, TR Adames, JW Snow - Apidologie, 2020 - Springer
The mechanisms by which pollen is digested by honey bees are incompletely understood.
Potential methods are thought to include pseudogermination, mechanical disruption, …
Potential methods are thought to include pseudogermination, mechanical disruption, …
[HTML][HTML] Stat3 Inhibition Is a Synthetic Lethal Vulnerability for Sf3b1-Mutated Hematopoietic Stem Cells
…, V Gupta, A Shastri, G Choudhary, M McKinstry… - Experimental …, 2019 - Elsevier
Hematopoietic stem and progenitor cells (HSPCs) maintain hematopoiesis throughout the
lifetime of an organism. HSPC dysfunction can lead to disorders such as myelodysplastic …
lifetime of an organism. HSPC dysfunction can lead to disorders such as myelodysplastic …
Sf3b1 Regulation of Jak/Stat Signaling Is Essential for Hematopoietic Stem Cell Formation
Hematopoietic stem cells (HSCs) maintain the hematopoietic system throughout the lifetime
of an organism. During embryonic development, HSCs emerge through an endothelial-to-…
of an organism. During embryonic development, HSCs emerge through an endothelial-to-…
Selective Targeting of Splicing Factor Mutant Hematopoietic Stem and Progenitor Cells Via STAT3 Inhibition
…, A Leal-Cervantes, S Aluri, K Pradhan, M McKinstry… - Blood, 2021 - Elsevier
Myelodysplastic syndrome (MDS) is a bone marrow failure disorder driven by dysfunction of
hematopoietic stem and progenitor cells (HSPCs). Patient sequencing studies over the last …
hematopoietic stem and progenitor cells (HSPCs). Patient sequencing studies over the last …