m6A RNA methylation, a new hallmark in virus-host interactions
M Brocard, A Ruggieri, N Locker - Journal of General …, 2017 - microbiologyresearch.org
The role of m 6 A methylation of RNA has remained elusive for decades, but recent
technological advances are now allowing the mapping of the m 6 A methylation landscape at …
technological advances are now allowing the mapping of the m 6 A methylation landscape at …
[HTML][HTML] Norovirus infection results in eIF2α independent host translation shut-off and remodels the G3BP1 interactome evading stress granule formation
M Brocard, V Iadevaia, P Klein, B Hall, G Lewis… - PLoS …, 2020 - journals.plos.org
Viral infections impose major stress on the host cell. In response, stress pathways can rapidly
deploy defence mechanisms by shutting off the protein synthesis machinery and triggering …
deploy defence mechanisms by shutting off the protein synthesis machinery and triggering …
Extensive translation of small open reading frames revealed by Poly-Ribo-Seq
…, RJ Phillips, U Amin, MAS Mumtaz, M Brocard… - elife, 2014 - elifesciences.org
10.7554/eLife.03528.001 Thousands of small Open Reading Frames (smORFs) with the
potential to encode small peptides of fewer than 100 amino acids exist in our genomes. …
potential to encode small peptides of fewer than 100 amino acids exist in our genomes. …
Rabies virus matrix protein interplay with eIF3, new insights into rabies virus pathogenesis
…, E Real, AM Borman, M Brocard… - Nucleic acids …, 2007 - academic.oup.com
Viral proteins are frequently multifunctional to accommodate the high density of information
encoded in viral genomes. Matrix (M) protein of negative-stranded RNA viruses such as …
encoded in viral genomes. Matrix (M) protein of negative-stranded RNA viruses such as …
Pumilio directs deadenylation-associated translational repression of the cyclin-dependent kinase 1 activator RGC-32
M Brocard, S Khasnis, CD Wood… - Nucleic acids …, 2018 - academic.oup.com
Response gene to complement-32 (RGC-32) activates cyclin-dependent kinase 1, regulates
the cell cycle and is deregulated in many human tumours. We previously showed that RGC-…
the cell cycle and is deregulated in many human tumours. We previously showed that RGC-…
[HTML][HTML] Infectious bronchitis virus regulates cellular stress granule signaling
MJ Brownsword, N Doyle, M Brocard, N Locker… - Viruses, 2020 - mdpi.com
Viruses must hijack cellular translation machinery to express viral genes. In many cases,
this is impeded by cellular stress responses. These stress responses result in the global …
this is impeded by cellular stress responses. These stress responses result in the global …
Evidence that PTB does not stimulate HCV IRES-driven translation
M Brocard, S Paulous, AV Komarova, V Deveaux… - Virus Genes, 2007 - Springer
It is now well established that Hepatitis C Virus (HCV) translation is driven by an Internal
Ribosome Entry Site (IRES) resulting in cap-independent translation. Such a mechanism …
Ribosome Entry Site (IRES) resulting in cap-independent translation. Such a mechanism …
Translation initiation factors and active sites of protein synthesis co-localize at the leading edge of migrating fibroblasts
M Willett, M Brocard, A Davide, SJ Morley - Biochemical Journal, 2011 - portlandpress.com
Cell migration is a highly controlled essential cellular process, often dysregulated in tumour
cells, dynamically controlled by the architecture of the cell. Studies involving cellular …
cells, dynamically controlled by the architecture of the cell. Studies involving cellular …
Effects of the Sabin-like mutations in domain V of the internal ribosome entry segment on translational efficiency of the Coxsackievirus B3
…, J Gharbi, S Paulous, M Brocard… - Molecular Genetics and …, 2006 - Springer
The domain V within the internal ribosome entry segment (IRES) of poliovirus (PV) is expected
to be important in its own neurovirulence because it contains an attenuating mutation in …
to be important in its own neurovirulence because it contains an attenuating mutation in …
The case for mRNA 5′ and 3′ end cross talk during translation in a eukaryotic cell
AV Komarova, M Brocard, KM Kean - Progress in nucleic acid research and …, 2006 - Elsevier
Publisher Summary This chapter discusses evidence and hypotheses concerning the place
of RNA circularization during messenger RNA (mRNA) translation. It provides a short list that …
of RNA circularization during messenger RNA (mRNA) translation. It provides a short list that …