The mechanisms involved in the epithelial to mesenchymal transition (EMT) are integrated
in concert with master developmental and oncogenic pathways regulating in tumor growth, …

Reduction of epithelial cell–cell adhesion via the transcriptional repression of cadherins in
combination with the acquisition of mesenchymal properties are key determinants of epithelial…

Tumor invasion is the outcome of a complex interplay between cancer cells and the stromal
environment. Considering the contribution of the stromal environment, we developed a …

Colorectal cancer (CRC) is a common tumor type with a high mortality rate, in part due to
intrinsic drug resistance. Although bevacizumab, a VEGF-directed neutralizing antibody, is …

There is an urgent need for specific antiviral treatments directed against SARS-CoV-2 to
prevent the most severe forms of COVID-19. By drug repurposing, affordable therapeutics could …

Epithelial-to-mesenchymal transition (EMT) mediates cancer cell invasion, metastasis, and
drug resistance, but its impact on immune surveillance has not been explored. In this study, …

WISP-2/CCN5 is an estrogen-regulated member of the “connective tissue growth factor/cysteine-rich
61/nephroblastoma overexpressed” (CCN) family of the cell growth and …

Estrogen receptors (ER) are ligand-dependent transcription factors that regulate growth,
differentiation, and maintenance of cellular functions in a wide variety of tissues. We report here …

Introduction: Endometrial cancer (EC) is the most important gynecological cancer in terms of
incidence. microRNAs (miRs), which are post-transcriptional regulators implicated in a …

Estrogens induce cell proliferation in target tissues by stimulating progression through the G
1 phase of the cell cycle. Induction of cyclin D1 expression is a critical feature of the …