Autophagy is a fundamental biological process of the eukaryotic cell contributing to diverse
cellular and physiological functions including cell-autonomous defense against intracellular …

Working in the category of based spaces, we give the basic theory of diagram spaces and
diagram spectra. These are functors for a suitable small topological category . When is …

Autophagy is a cell biological pathway affecting immune responses. In vitro, autophagy acts
as a cell-autonomous defense against Mycobacterium tuberculosis, but its role in vivo is …

Autophagy, once viewed exclusively as a cytoplasmic auto-digestive process, has its less
intuitive but biologically distinct non-degradative roles. One manifestation of these functions of …

The last few years have seen a revolution in our understanding of the foundations of stable
homotopy theory. Many symmetric monoidal model categories of spectra whose homotopy …

Autophagy, a homeostatic process whereby eukaryotic cells target cytoplasmic cargo for
degradation, plays a broad role in health and disease states. Here we screened the TRIM family …

Dendritic cells (DC), including those of the skin, act as sentinels for intruding microorganisms.
In the epidermis, DC (termed Langerhans cells, LC) are sessile and screen their …

The present paradigms of selective autophagy in mammalian cells cannot fully explain the
specificity and selectivity of autophagic degradation. In this paper, we report that a subset of …

IRGM, encoded by a uniquely human gene conferring risk for inflammatory diseases, affects
autophagy through an unknown mechanism. Here, we show how IRGM controls autophagy. …

Let F p denote the field with p elements and F ̄ p its algebraic closure. We show that the
singular cochain functor with coefficients in F ̄ p induces a contravariant equivalence between …