Alzheimer’s disease is a progressive neurodegenerative disease most often associated
with memory deficits and cognitive decline, although less common clinical presentations are …

Alzheimer’s disease (AD) is the consequence of neuronal death and brain atrophy associated
with the aggregation of protein tau into fibrils. Thus disaggregation of tau fibrils could be a …

The hemizygous R47H variant of triggering receptor expressed on myeloid cells 2 (TREM2),
a microglia-specific gene in the brain, increases risk for late-onset Alzheimer’s disease (AD)…

Tauopathies are defined by assembly of the microtubule associated protein tau into
filamentous tangles and classified by the predominant tau isoform within these aggregates. The …

Approximately half of Alzheimer’s disease (AD) brains have concomitant Lewy pathology at
autopsy, suggesting that α-synuclein (α-SYN) aggregation is a regulated event in the …

Progressive apraxia of speech is a neurodegenerative syndrome affecting spoken
communication. Molecular pathology, biochemistry, genetics, and longitudinal imaging were …

In order to determine the frequency of microtubule-associated protein tau gene (MAPT)
mutations and rare variants in CBD, we performed a systematic sequence analysis of MAPT …

CSF-1R haploinsufficiency causes adult-onset leukoencephalopathy with axonal spheroids
and pigmented glia (ALSP). Previous studies in the Csf1r +/− mouse model of ALSP …

In Alzheimer's disease (AD) and tauopathies, tau aggregation accompanies progressive
neurodegeneration. Aggregated tau appears to spread between adjacent neurons and …

Importance The association between the microtubule-associated protein tau (MAPT) H1
haplotype and the risk of progressive supranuclear palsy (PSP) has been well documented. …