Protein synthesis consumes a large fraction of available resources in the cell. When bacteria
encounter unfavorable conditions and cease to grow, specialized mechanisms are in place …

Ribosome hibernation is a universal translation stress response found in bacteria as well as
plant plastids. The term was coined almost two decades ago and despite recent insights …

Production of the translation apparatus of E. coli is carefully matched to the demand for
protein synthesis posed by a given growth condition. For example, the fraction of RNA …

Biogenic polyamines are natural aliphatic polycations formed from amino acids by
biochemical pathways that are highly conserved from bacteria to humans. Their cellular …

Escherichia coli cells respond to a period of famine by globally reorganizing their gene
expression. The changes are known as the stringent response, which is orchestrated by the …

Protein synthesis is the most energetically costly process in the cell. Consequently, it is a
tightly regulated process, and regulation of the resources allocated to the protein synthesis …

The vast majority of a bacterial population is killed when treated with a lethal concentration
of antibiotics. The time scale of this killing is often comparable with the bacterial generation …

Escherichia coli regulates its metabolism to adapt to changes in the environment, in particular
to stressful downshifts in nutrient quality. Such shifts elicit the so-called stringent response, …

Three out of the seven ribosomal RNA operons in Escherichia coli end in dual terminator
structures. Between the two terminators of each operon is a short sequence that we report here …

… Thomas Prossliner, Kenn Gerdes, Michael Askvad Sørensen, Kristoffer Skovbo Winther …
Michael Askvad Sørensen, Department of Biology, University of Copenhagen, Ole Maaløes …