Abstract Framework monoclonal antibodies have identified a population of human
lymphocytes that express the T3 glycoprotein but not the T-cell receptor (TCR) α- and β-subunits. …

IN contrast to sessile cell types, lymphocytes migrate through the vasculature to become
diffusely distributed in tissues or organized in lymphoid structures. A complex array of adhesion …

T LYMPHOCYTES express either αβ or γδ T-cell receptor heterodimers 1,2 . Most αβ T cells
recognize antigenic peptides bound to major histocompatibility complex molecules but the …

▪ Abstract This review summarizes the major features of CD1 genes and proteins, the patterns
of intracellular trafficking of CD1 molecules, and how they sample different intracellular …

MAJOR histocompatibility complex (MHC) class I and class II molecules bind immunogenic
peptides and present them to lymphocytes bearing the αβ T-cell antigen receptor (TCR) 1–4 . …

Previous studies have revealed that autoantibodies, complement components, and Fc receptors
each participate in the pathogenesis of erosive arthritis in K/BxN mice. However, it is not …

To define the cell populations that drive joint inflammation in rheumatoid arthritis (RA), we
applied single-cell RNA sequencing (scRNA-seq), mass cytometry, bulk RNA sequencing (…

Invariant natural killer T (iNKT) cells exist in a 'poised effector' state, which enables them to
rapidly produce cytokines following activation. Using a nearly monospecific T cell receptor, …

CD1d-restricted natural killer (NK)T cells are known to potently secrete T helper (Th)1 and
Th2 cytokines and to mediate cytolysis, but it is unclear how these contrasting functional …

CD4-CD8- (double negative [DN]) alpha/beta T cells are a largely uncharacterized
subpopulation of unknown function. To investigate whether these cells are selected to recognize …