Most protein phosphatases have little intrinsic substrate specificity, making selective
pharmacological inhibition of specific dephosphorylation reactions a challenging problem. In a …

O‐Glc NA cylation is an essential, nutrient‐sensitive post‐translational modification, but its
biochemical and phenotypic effects remain incompletely understood. To address this question…

The mechanism of apoptosis has been extensively characterized over the past decade, but
little is known about alternative forms of regulated cell death. Although stimulation of the Fas/…

O-linked β-N-acetylglucosamine (O-GlcNAc) is a reversible posttranslational modification
found on hundreds of nuclear and cytoplasmic proteins in higher eukaryotes. Despite its …

Caspases are a family of cysteine proteases that play important roles in regulating apoptosis.
A decade of research has generated a wealth of information on the signal transduction …

Autonomous agents have been increasingly used for military operations eg, casualty
extraction, explosive detection and disposals, reconnaissance and surveillance, supply …

Hundreds of mammalian nuclear and cytoplasmic proteins are reversibly glycosylated by O-linked
β-N-acetylglucosamine (O-GlcNAc) to regulate their function, localization, and stability…

Free fatty acids cause pancreatic β-cell apoptosis and may contribute to β-cell loss in type 2
diabetes via the induction of endoplasmic reticulum stress. Reductions in eukaryotic …

Bioorthogonal chemistry allows a wide variety of biomolecules to be specifically labeled and
probed in living cells and whole organisms. Here we discuss the history of bioorthogonal …

Plant development requires coordination among complex signaling networks to enhance
the plant's adaptation to changing environments. DELLAs, transcription regulators originally …