Myokit is a new powerful and versatile software tool for modeling and simulation of cardiac
cellular electrophysiology. Myokit consists of an easy-to-read modeling language, a graphical …

Cardiac electrophysiology models are among the most mature and well‐studied mathematical
models of biological systems. This maturity is bringing new challenges as models are …

Mathematical models of ionic currents are used to study the electrophysiology of the heart,
brain, gut, and several other organs. Increasingly, these models are being used predictively in …

Time series models are ubiquitous in science, arising in any situation where researchers seek
to understand how a system's behaviour changes over time. A key problem in time series …

The modelling of the electrophysiology of cardiac cells is one of the most mature areas of
systems biology. This extended concentration of research effort brings with it new challenges, …

Mathematical models of ion channels, which constitute indispensable components of action
potential models, are commonly constructed by fitting to whole-cell patch-clamp data. In a …

Predicting how pharmaceuticals may affect heart rhythm is a crucial step in drug development
and requires a deep understanding of a compound's action on ion channels. In vitro hERG …

We present here CellML 2.0, an XML-based language for describing and exchanging
mathematical models of physiological systems. MathML embedded in CellML documents is used …

Ion channel behavior can depend strongly on temperature, with faster kinetics at physiological
temperatures leading to considerable changes in currents relative to room temperature. …

Ordinary differential equation models are used to describe dynamic processes across
biology. To perform likelihood-based parameter inference on these models, it is necessary to …