Neuropathic pain is triggered by lesions to the somatosensory nervous system that alter its
structure and function so that pain occurs spontaneously and responses to noxious and …

Inflammatory pain manifests as spontaneous pain and pain hypersensitivity. Spontaneous
pain reflects direct activation of specific receptors on nociceptor terminals by inflammatory …

We report that GTP cyclohydrolase (GCH1), the rate-limiting enzyme for tetrahydrobiopterin (BH4)
synthesis, is a key modulator of peripheral neuropathic and inflammatory pain. BH4 is …

Background Rat oligonucleotide microarrays were used to detect changes in gene
expression in the dorsal root ganglion (DRG) 3 days following sciatic nerve transection (axotomy). …

Chronic pain is highly variable between individuals, as is the response to analgesics.
Although much of the variability in chronic pain and analgesic response is heritable, an …

Partial peripheral nerve injury in adult rats results in neuropathic pain-like hypersensitivity,
while that in neonatal rats does not, a phenomenon also observed in humans. We therefore …

TRPA1 is a nonselective cation channel expressed by nociceptors. Although it is widely
accepted that TRPA1 serves as a broad irritancy receptor for a variety of reactive chemicals, its …

Our understanding of chronic inflammatory and neuropathic pain at the molecular and cellular
level has developed at an extraordinary rate in recent years. Inflammatory, or neuropathic, …

We used a mouse with deletion of exons 4, 5, and 6 of the SCN11A (sodium channel,
voltage-gated, type XI, α) gene that encodes the voltage-gated sodium channel Na v 1.9 to assess …

The regenerative capacity of the injured CNS in adult mammals is severely limited, yet axons
in the peripheral nervous system (PNS) regrow, albeit to a limited extent, after injury. We …