Differential pathogenesis of respiratory syncytial virus clinical isolates in BALB/c mice

…, K Sakamoto, DC Newcomb, MG Currier… - Journal of …, 2011 - Am Soc Microbiol
Airway mucus is a hallmark of respiratory syncytial virus (RSV) lower respiratory tract illness.
Laboratory RSV strains differentially induce airway mucus production in mice. Here, we …

The respiratory syncytial virus fusion protein and neutrophils mediate the airway mucin response to pathogenic respiratory syncytial virus infection

KL Stokes, MG Currier, K Sakamoto, S Lee… - Journal of …, 2013 - Am Soc Microbiol
Respiratory syncytial virus (RSV) is the leading cause of death due to a viral etiology in infants.
RSV disease is characterized by epithelial desquamation, neutrophilic bronchiolitis and …

[HTML][HTML] EGFR interacts with the fusion protein of respiratory syncytial virus strain 2-20 and mediates infection and mucin expression

MG Currier, S Lee, CC Stobart, AL Hotard… - PLoS …, 2016 - journals.plos.org
Respiratory syncytial virus (RSV) is the major cause of viral lower respiratory tract illness in
children. In contrast to the RSV prototypic strain A2, clinical isolate RSV 2–20 induces airway …

[HTML][HTML] Differential neutralization and inhibition of SARS-CoV-2 variants by antibodies elicited by COVID-19 mRNA vaccines

…, N Jiang, H Di, G Bonenfant, L Mills, M Currier… - Nature …, 2022 - nature.com
The evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted
in the emergence of new variant lineages that have exacerbated the COVID-19 pandemic…

[HTML][HTML] A live RSV vaccine with engineered thermostability is immunogenic in cotton rats despite high attenuation

…, RJ Pickles, K Sakamoto, S Lee, MG Currier… - Nature …, 2016 - nature.com
Respiratory syncytial virus (RSV) is a leading cause of infant hospitalization and there remains
no pediatric vaccine. RSV live-attenuated vaccines (LAVs) have a history of safe testing …

[HTML][HTML] A polyvalent inactivated rhinovirus vaccine is broadly immunogenic in rhesus macaques

S Lee, MT Nguyen, MG Currier, JB Jenkins… - Nature …, 2016 - nature.com
As the predominant aetiological agent of the common cold, human rhinovirus (HRV) is the
leading cause of human infectious disease. Early studies showed that a monovalent formalin-…

Vaccine-Elicited CD8+ T Cells Protect against Respiratory Syncytial Virus Strain A2-Line19F-Induced Pathogenesis in BALB/c Mice

S Lee, KL Stokes, MG Currier, K Sakamoto… - Journal of …, 2012 - Am Soc Microbiol
CD8 + T cells may contribute to vaccines for respiratory syncytial virus (RSV). Compared to
CD8 + T cells responding to RSV infection, vaccine-elicited anti-RSV CD8 + T cells are less …

[HTML][HTML] Susceptibility to SARS-CoV-2 of cell lines and substrates commonly used to diagnose and isolate influenza and other viruses

…, J Hossain, N Jiang, G Larson, M Currier… - Emerging infectious …, 2021 - ncbi.nlm.nih.gov
Co-infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other
viruses has been reported. We evaluated cell lines commonly used to isolate viruses and …

Identification of residues in the human respiratory syncytial virus fusion protein that modulate fusion activity and pathogenesis

AL Hotard, S Lee, MG Currier, JE Crowe Jr… - Journal of …, 2015 - Am Soc Microbiol
Human respiratory syncytial virus (RSV) lower respiratory tract infection can result in
inflammation and mucus plugging of airways. RSV strain A2-line19F induces relatively high viral …

Respiratory syncytial virus attachment glycoprotein contribution to infection depends on the specific fusion protein

J Meng, AL Hotard, MG Currier, S Lee… - Journal of …, 2016 - Am Soc Microbiol
Human respiratory syncytial virus (RSV) is an important pathogen causing acute lower
respiratory tract disease in children. The RSV attachment glycoprotein (G) is not required for …