The development of noninvasive methods to detect and monitor tumors continues to be a
major challenge in oncology. We used digital polymerase chain reaction–based technologies …

Neuroblastoma is a malignancy of the developing sympathetic nervous system that often
presents with widespread metastatic disease, resulting in survival rates of less than 50%. To …

The majority of patients with neuroblastoma have tumors that initially respond to chemotherapy,
but a large proportion will experience therapy-resistant relapses. The molecular basis of …

PURPOSE Treatment planning for children with neuroblastoma requires accurate assessment
of prognosis. The most recent Children's Oncology Group (COG) risk classification system …

Neuroblastomas are tumors of peripheral sympathetic neurons and are the most common
solid tumor in children. To determine the genetic basis for neuroblastoma, we performed whole…

Genetic studies have established anaplastic lymphoma kinase (ALK), a cell surface
receptor tyrosine kinase, as a tractable molecular target in neuroblastoma. We describe …

Oncogenic Myc alters mitochondrial metabolism, making it dependent on exogenous glutamine
(Gln) for cell survival. Accordingly, Gln deprivation selectively induces apoptosis in MYC-…

Deletions of the long arm of chromosome 11 (11q) have been noted in primary neuroblastomas,
but a comprehensive analysis has not been performed. Therefore, we analysed 331 …

Importance Induction chemotherapy followed by high-dose therapy with autologous stem cell
transplant and subsequent antidisialoganglioside antibody immunotherapy is standard of …

Neuroblastoma is a frequently lethal childhood tumor in which MYC gene deregulation,
commonly as MYCN amplification, portends poor outcome. Identifying the requisite biopathways …