Haematopoietic stem cells (HSCs) are responsible for the lifelong production of blood cells.
The accumulation of DNA damage in HSCs is a hallmark of ageing and is probably a major …

In this study, we present integrated quantitative proteome, transcriptome, and methylome
analyses of hematopoietic stem cells (HSCs) and four multipotent progenitor (MPP) populations…

Hematopoietic stem cells (HSCs) mediate regeneration of the hematopoietic system following
injury, such as following infection or inflammation. These challenges impair HSC function, …

Infections are associated with extensive platelet consumption, representing a high risk for
health. However, the mechanism coordinating the rapid regeneration of the platelet pool …

Non-alcoholic fatty liver disease ranges from steatosis to non-alcoholic steatohepatitis (NASH),
potentially progressing to cirrhosis and hepatocellular carcinoma (HCC). Here, we show …

Blood and immune cells derive from multipotent hematopoietic stem cells (HSCs).
Classically, stem and progenitor populations have been considered discrete homogeneous …

The rates and patterns of somatic mutation in normal tissues are largely unknown outside of
humans 1 , 2 , 3 , 4 , 5 , 6 – 7 . Comparative analyses can shed light on the diversity of …

Chromosomal rearrangements involving the H3K4 methyltransferase mixed-lineage leukemia
(MLL) trigger aberrant gene expression in hematopoietic progenitors and give rise to an …

Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is known to contain an active-site
cysteine residue undergoing oxidation in response to hydrogen peroxide, leading to rapid …

Reducing expression of the fetal hemoglobin (HbF) repressor BCL11A leads to a simultaneous
increase in γ-globin expression and reduction in β-globin expression. Thus, there is …