Abstract Changes in cellular growth and dramatic alterations in cell morphology and adhesion
are common features of cells transformed by oncogenic protein tyrosine kinases, such as …

Integrins receive signals from other receptors that lead to activation of ligand binding (inside-out
signaling) and matrix assembly. Upon binding ligands, they also activate intracellular …

Expression of the Rous sarcoma virus-encoded oncoprotein, pp60v-src, subverts the normal
regulation of cell growth, which results in oncogenic transformation. This process requires …

The phosphorylation of protein tyrosine kinases (PTKs) on tyrosine residues is a critical
regulatory event that modulates catalytic activity and triggers the physical association of PTKs …

Recent studies have demonstrated that mitogen-activated protein kinases (MAPKs), including
Jun N-terminus kinase (JNK), p38 and Erk, play crucial roles in cell migration. JNK, for …

The integrins have recently been implicated in signal transduction. A likely mediator of
integrin signaling is focal adhesion kinase (pp125FAK or FAK), a structurally distinct protein …

The focal adhesion kinase, FAK, is an important component of an integrin-dependent
signaling pathway, which functions to transmit signals from the extracellular matrix into the …

Paxillin is a focal adhesion-associated, phosphotyrosine-containing protein that may play a
role in several signaling pathways. Paxillin contains a number of motifs that mediate protein–…

Paxillin, a focal-adhesion-associated protein, becomes phosphorylated in response to a
number of stimuli which also induce the tyrosine phosphorylation of the focal-adhesion-…

Src family nonreceptor protein tyrosine kinases transduce signals that control normal cellular
processes such as cell proliferation, adhesion and motility. Normally, cellular Src is held in …