Key points Ketamine is a common anaesthetic agent used in research and more recently as
medication in treatment of depression. It has known effects on inhibition of interneurons and …

Advances in chip-scale photonic-electronic integration are enabling a new generation of
foundry-manufacturable implantable silicon neural probes incorporating nanophotonic …

Hearing deficits impact on the communication with the external world and severely compromise
perception of the surrounding. Deafness can be caused by particular mutations in the …

Reward associations during auditory learning induce cortical plasticity in the primary auditory
cortex. A prominent source of such influence is the ventral tegmental area (VTA), which …

The primary auditory cortex (A1) is an essential, integrative node that encodes the behavioral
relevance of acoustic stimuli, predictions, and auditory-guided decision-making. However, …

Cortical release of the neurotransmitter dopamine has been implied in adapting cortical
processing with respect to various functions including coding of stimulus salience, expectancy, …

Engineered neural tissues serve as models for studying neurological conditions and drug
screening. Besides observing the cellular physiological properties, in situ monitoring of …

In brain activity mapping experiments using optogenetics, patterned illumination is crucial
for deterministic and localized stimulation of neurons. However, due to optical scattering in …

The exploration of neural circuitry is essential for understanding the computational mechanisms
and physiology of the brain. Despite significant advances in materials and fabrication …

Implantable neural probes with microfluidic channels have been previously demonstrated for
multi-drug delivery [1] and neurochemical sampling [2] in brain tissue. We have previously …