Antigen-specific memory B cell development

LJ McHeyzer-Williams… - Annu. Rev …, 2005 - annualreviews.org
▪ Abstract Helper T (Th) cell–regulated B cell immunity progresses in an ordered cascade of
cellular development that culminates in the production of antigen-specific memory B cells. …

[PDF][PDF] Follicular helper T cells: lineage and location

…, LJ McHeyzer-Williams, MG McHeyzer-Williams - Immunity, 2009 - cell.com
Follicular helper T (Tfh) cells are the class of effector T helper cells that regulates the step-wise
development of antigen-specific B cell immunity in vivo. Deployment of CXCR5 + Tfh cells …

B cell memory and the long-lived plasma cell

MG McHeyzer-Williams, R Ahmed - Current opinion in immunology, 1999 - Elsevier
… memory and the long-lived plasma cell Michael G McHeyzer-Williams* … (g) Positive selection
may lead to re-entry … the GC cycle, or exit into the post-G<: compartment. We will consider all …

Phenotypic analysis of antigen-specific T lymphocytes

…, PJR Goulder, DH Barouch, MG McHeyzer-Williams… - Science, 1996 - science.org
Identification and characterization of antigen-specific T lymphocytes during the course of an
immune response is tedious and indirect. To address this problem, the peptide-major …

[PDF][PDF] Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells

…, LJ McHeyzer-Williams, J Liao, MG McHeyzer-Williams… - Immunity, 2003 - cell.com
… cellcapacity upon adoptive transfer (McHeyzer-Williams et … (McHeyzer-Williams, 2003).
CD138 B220 memory B cells recirculate through spleen and peripheral LNs (McHeyzer-Williams

In vivo–activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines

KM Ansel, LJ McHeyzer-Williams, VN Ngo… - The Journal of …, 1999 - rupress.org
Migration of antigen-activated CD4 T cells to B cell areas of lymphoid tissues is important for
mounting T cell–dependent antibody responses. Here we show that CXC chemokine …

The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding

N Fazilleau, LJ McHeyzer-Williams, H Rosen… - Nature …, 2009 - nature.com
How follicular helper T cells (T FH cells) differentiate to regulate B cell immunity is critical for
effective protein vaccination. Here we define three transcription factor T-bet–expressing …

Class-switched memory B cells remodel BCRs within secondary germinal centers

LJ McHeyzer-Williams, PJ Milpied, SL Okitsu… - Nature …, 2015 - nature.com
Effective vaccines induce high-affinity memory B cells and durable antibody responses
through accelerated mechanisms of natural selection. Secondary changes in antibody …

Antigen-specific development of primary and memory T cells in vivo

MG McHeyzer-Williams, MM Davis - Science, 1995 - science.org
The expansion and contraction of specific helper T cells in the draining lymph nodes of normal
mice after injection with antigen was followed. T cell receptors from purified primary and …

Ligation-anchored PCR: a simple amplification technique with single-sided specificity.

AB Troutt, MG McHeyzer-Williams… - Proceedings of the …, 1992 - National Acad Sciences
A simple, efficient, and sensitive technique has been developed for amplification of cDNAs
encoding molecules with 5' regions of unknown sequence. In this ligation-anchored PCR, T4 …