User profiles for Michael Gandal
 | Michael J. Gandal, MD/PhDWilliam & Noreen Hetznecker Associate Professor of Psychiatry, University of Pennsylvania Verified email at pennmedicine.upenn.edu Cited by 15312 |
Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder
INTRODUCTION Our understanding of the pathophysiology of psychiatric disorders, including
autism spectrum disorder (ASD), schizophrenia (SCZ), and bipolar disorder (BD), lags …
autism spectrum disorder (ASD), schizophrenia (SCZ), and bipolar disorder (BD), lags …
Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders
Genetic and genomic approaches have implicated hundreds of genetic loci in neurodevelopmental
disorders and neurodegeneration, but mechanistic understanding continues to lag …
disorders and neurodegeneration, but mechanistic understanding continues to lag …
The road to precision psychiatry: translating genetics into disease mechanisms
Hundreds of genetic loci increasing risk for neuropsychiatric disorders have recently been
identified. This success, perhaps paradoxically, has posed challenges for therapeutic …
identified. This success, perhaps paradoxically, has posed challenges for therapeutic …
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide
association study of 41,917 bipolar disorder cases and 371,549 controls of European …
association study of 41,917 bipolar disorder cases and 371,549 controls of European …
Gamma synchrony: towards a translational biomarker for the treatment-resistant symptoms of schizophrenia
The lack of efficacy for antipsychotics with respect to negative symptoms and cognitive deficits
is a significant obstacle for the treatment of schizophrenia. Developing new drugs to target …
is a significant obstacle for the treatment of schizophrenia. Developing new drugs to target …
Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder
Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …
[PDF][PDF] Human gut microbiota from autism spectrum disorder promote behavioral symptoms in mice
Autism spectrum disorder (ASD) manifests as alterations in complex human behaviors including
social communication and stereotypies. In addition to genetic risks, the gut microbiome …
social communication and stereotypies. In addition to genetic risks, the gut microbiome …
Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap
MJ Gandal, JR Haney, NN Parikshak, V Leppa… - Science, 2018 - science.org
The predisposition to neuropsychiatric disease involves a complex, polygenic, and pleiotropic
genetic architecture. However, little is known about how genetic variants impart brain …
genetic architecture. However, little is known about how genetic variants impart brain …
Comprehensive functional genomic resource and integrative model for the human brain
INTRODUCTION Strong genetic associations have been found for a number of psychiatric
disorders. However, understanding the underlying molecular mechanisms remains …
disorders. However, understanding the underlying molecular mechanisms remains …
Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism
Autism spectrum disorder (ASD) involves substantial genetic contributions. These contributions
are profoundly heterogeneous but may converge on common pathways that are not yet …
are profoundly heterogeneous but may converge on common pathways that are not yet …