Purpose The hepatocyte growth factor/c-MET axis is implicated in tumor cell proliferation,
survival, and angiogenesis. ARQ 197 is an oral, selective, non–adenosine triphosphate …

Background Functional magnetic resonance imaging (MRI) studies have shown that APOE
ε2- and ε4-carriers have similar patterns of blood-oxygenation-level-dependent (BOLD) …

OBJECTIVE. The purpose of this study was to compare apparent diffusion coefficients, metabolic
ratios, and vascularity values within histologically defined prostate tumors with those in …

Purpose To assess the repeatability of apparent diffusion coefficient (ADC) estimates in
extracranial soft-tissue diffusion-weighted magnetic resonance imaging across a wide range of …

This study aims to map the acute effects of caffeine ingestion on grey matter oxygen metabolism
and haemodynamics with a novel MRI method. Sixteen healthy caffeine consumers (8 …

Functional magnetic resonance imaging (fMRI) is an essential workhorse of modern
neuroscience, providing valuable insight into the functional organisation of the brain. The …

Cerebral energy deficiency is increasingly recognised as an important feature of multiple
sclerosis (MS). Until now, we have lacked non-invasive imaging methods to quantify energy …

The measurement of the absolute rate of cerebral metabolic oxygen consumption (CMRO 2
) is likely to offer a valuable biomarker in many brain diseases and could prove to be …

Dual-calibrated fMRI is a multi-parametric technique that allows for the quantification of the
resting oxygen extraction fraction (OEF), the absolute rate of cerebral metabolic oxygen …

Hyperoxia is known to cause an increase in the blood oxygenation level dependent (BOLD)
signal that is primarily localised to the venous vasculature. This contrast mechanism has …