Layering of neurons in the cerebral cortex and cerebellum requires Reelin, an extracellular
matrix protein, and mammalian Disabled (mDab1), a cytosolic protein that activates tyrosine …

Alternative splicing has a major role in cardiac adaptive responses, as exemplified by the
isoform switch of the sarcomeric protein titin, which adjusts ventricular filling. By positional …

Titin is a giant vertebrate striated muscle protein with critical importance for myofibril elasticity
and structural integrity. We show here that the complete sequence of the human titin gene …

sorLA (sorting protein-related receptor) is a type-1 membrane protein of unknown function
that is expressed in neurons. Its homology to sorting receptors that shuttle between the …

Vascular smooth muscle cell (SMC) proliferation and migration are important events in the
development of atherosclerosis. The low-density lipoprotein receptor–related protein (LRP1) …

The recent discovery of heterozygous human mutations that truncate full-length titin (TTN, an
abundant structural, sensory, and signaling filament in muscle) as a common cause of end-…

The African naked mole-rat’s (Heterocephalus glaber) social and subterranean lifestyle
generates a hypoxic niche. Under experimental conditions, naked mole-rats tolerate hours of …

The members of the low density lipoprotein (LDL) receptor gene family bind a broad spectrum
of extracellular ligands. Traditionally, they had been regarded as mere cargo receptors …

The multifunctional low density lipoprotein (LDL) receptor-related protein (LRP) has been
postulated to participate in a number of diverse physiological and pathological processes …

Atrial natriuretic peptide (ANP) is an important regulator of arterial blood pressure. The
mechanisms mediating its hypotensive effects are complex and involve the inhibition of the …