~ 56”~, a lymphocyte-specific member of the SIC family of cytoplasmic protein-tyrosine kinases,
is associated noncovalently with the cell surface glycoproteins CD4 and CD8, which are …

The tumor suppressor gene p53 regulates multiple cellular responses to DNA damage, but
the transcriptional targets that specify these responses are incompletely understood. We …

We describe the comprehensive characterization of homeodomain DNA-binding specificities
from a metazoan genome. The analysis of all 84 independent homeodomains from D. …

We have used genetic and microarray analysis to determine how ionizing radiation (IR)
induces p53-dependent transcription and apoptosis in Drosophila melanogaster. IR induces …

A new method for the detection of various lipid hydroperoxides and hydrogen peroxide at the
picomole level has been developed by combining an HPLC system with an ultrasensitive …

The DNA-binding specificities of transcription factors can be used to computationally predict
cis-regulatory modules (CRMs) that regulate gene expression 1 . However, the absence of …

FlyFactorSurvey (http://pgfe.umassmed.edu/TFDBS/) is a database of DNA binding specificities
for Drosophila transcription factors (TFs) primarily determined using the bacterial one-…

CRISPR-Cas systems are a diverse family of RNA-protein complexes in bacteria that target
foreign DNA sequences for cleavage. Derivatives of these complexes have been engineered …

Specificity data for groups of transcription factors (TFs) in a common regulatory network can
be used to computationally identify the location of cis -regulatory modules in a genome. The …

The CRISPR-Cas9 system is commonly used in biomedical research; however, the precision
of Cas9 is suboptimal for applications that involve editing a large population of cells (for …