LINGO3 regulates mucosal tissue regeneration and promotes TFF2 dependent recovery from colitis
Aim: Recovery of damaged mucosal surfaces following inflammatory insult requires diverse
regenerative mechanisms that remain poorly defined. Previously, we demonstrated that the …
regenerative mechanisms that remain poorly defined. Previously, we demonstrated that the …
[HTML][HTML] A common mechanism of cellular death induced by bactericidal antibiotics
MA Kohanski, DJ Dwyer, B Hayete, CA Lawrence… - Cell, 2007 - cell.com
Antibiotic mode-of-action classification is based upon drug-target interaction and whether
the resultant inhibition of cellular function is lethal to bacteria. Here we show that the three …
the resultant inhibition of cellular function is lethal to bacteria. Here we show that the three …
LINGO3 interacts with Trefoil factor 2 to enforce mucosal barrier integrity and drive tissue repair during colitis
…, M Samsouk, S Srivatsa, LY Hung, MH Kohanski… - bioRxiv, 2018 - biorxiv.org
Mucosal epithelia are constantly exposed to damaging stimuli from mechanical, chemical,
or biologic entities, and depend on rapid repair mechanisms to maintain tissue homeostasis …
or biologic entities, and depend on rapid repair mechanisms to maintain tissue homeostasis …
[PDF][PDF] Sublethal antibiotic treatment leads to multidrug resistance via radical-induced mutagenesis
MA Kohanski, MA DePristo, JJ Collins - Molecular cell, 2010 - cell.com
Antibiotic resistance arises through mechanisms such as selection of naturally occurring
resistant mutants and horizontal gene transfer. Recently, oxidative stress has been implicated …
resistant mutants and horizontal gene transfer. Recently, oxidative stress has been implicated …
Role of reactive oxygen species in antibiotic action and resistance
DJ Dwyer, MA Kohanski, JJ Collins - Current opinion in microbiology, 2009 - Elsevier
The alarming spread of bacterial strains exhibiting resistance to current antibiotic therapies
necessitates that we elucidate the specific genetic and biochemical responses underlying …
necessitates that we elucidate the specific genetic and biochemical responses underlying …
[HTML][HTML] Mistranslation of membrane proteins and two-component system activation trigger antibiotic-mediated cell death
MA Kohanski, DJ Dwyer, J Wierzbowski, G Cottarel… - Cell, 2008 - cell.com
Aminoglycoside antibiotics, such as gentamicin and kanamycin, directly target the ribosome,
yet the mechanisms by which these bactericidal drugs induce cell death are not fully …
yet the mechanisms by which these bactericidal drugs induce cell death are not fully …
How antibiotics kill bacteria: from targets to networks
MA Kohanski, DJ Dwyer, JJ Collins - Nature Reviews Microbiology, 2010 - nature.com
Antibiotic drug–target interactions, and their respective direct effects, are generally well
characterized. By contrast, the bacterial responses to antibiotic drug treatments that contribute to …
characterized. By contrast, the bacterial responses to antibiotic drug treatments that contribute to …
Review of indoor aerosol generation, transport, and control in the context of COVID‐19
The coronavirus disease‐2019 (COVID‐19) pandemic has heightened the awareness of
aerosol generation by human expiratory events and their potential role in viral respiratory …
aerosol generation by human expiratory events and their potential role in viral respiratory …
Gyrase inhibitors induce an oxidative damage cellular death pathway in Escherichia coli
DJ Dwyer, MA Kohanski, B Hayete… - Molecular systems …, 2007 - embopress.org
Modulation of bacterial chromosomal supercoiling is a function of DNA gyrase‐catalyzed
strand breakage and rejoining. This reaction is exploited by both antibiotic and proteic gyrase …
strand breakage and rejoining. This reaction is exploited by both antibiotic and proteic gyrase …
Clinically relevant mutations in core metabolic genes confer antibiotic resistance
Although metabolism plays an active role in antibiotic lethality, antibiotic resistance is generally
associated with drug target modification, enzymatic inactivation, and/or transport rather …
associated with drug target modification, enzymatic inactivation, and/or transport rather …