Mechanisms that integrate the metabolic state of a cell with regulatory pathways are necessary
to maintain cellular homeostasis. Endogenous, intrinsically reactive metabolites can form …

The emerging use of covalent ligands as chemical probes and drugs would benefit from an
expanded repertoire of cysteine-reactive electrophiles for efficient and diverse targeting of …

KEAP1 (Kelch-like ECH-associated protein), a cytoplasmic repressor of the oxidative stress
responsive transcription factor Nuclear factor erythroid 2-related factor 2 (NRF2), senses the …

NRF2 serves as the master regulator of oxidative stress resistance in mammalian cells.
Although NRF2 activation decreases tumorigenic events in normal cells, accumulating evidence …

Expression of the transcription factor FOXC2 is induced and necessary for successful
epithelial–mesenchymal transition, a developmental program that when activated in cancer …

Disrupted circadian rhythmicity is a prominent feature of modern society and has been
designated as a probable carcinogen by the World Health Organization. However, the biological …

Fibrosis, a disease in which excessive amounts of connective tissue accumulate in response
to physical damage and/or inflammatory insult, affects nearly every tissue in the body and …

The transcriptional coactivator Yes-associated protein 1 (YAP) orchestrates a proproliferative
transcriptional program that controls the fate of somatic stem cells and the regenerative …

The NRF transcription factors NRF1, NRF2, and NRF3, are a subset of Cap‘n’collar
transcriptional regulators which modulate the expression of genes harboring antioxidant-response …

Cellular proteostasis is maintained by stress-responsive signaling pathways such as the
heat shock response (HSR), the oxidative stress response (OSR), and the unfolded protein …