Amyloid fibrils formed from different proteins, each associated with a particular disease,
contain a common cross-β spine. The atomic architecture of a spine, from the fibril-forming …

Determining protein functions from genomic sequences is a central goal of bioinformatics.
We present a method based on the assumption that proteins that function together in a …

The availability of over 20 fully sequenced genomes has driven the development of new
methods to find protein function and interactions. Here we group proteins by correlated …

Tristetraprolin (TTP) is a widely expressed potential transcription factor that contains two
unusual CCCH zinc fingers and is encoded by the immediate–early response gene, Zfp-36. …

▪ Abstract Helioseismology has transformed our knowledge of the Sun's rotation. Earlier
studies revealed the Sun's surface rotation, but now a detailed observational picture has been …

A major challenge in drug discovery is to distinguish the molecular targets of a bioactive
compound from the hundreds to thousands of additional gene products that respond indirectly to …

Based on the crystal structure of the cross-β spine formed by the peptide NNQQNY, we
have developed a computational approach for identifying those segments of amyloidogenic …

Understanding the molecular determinants of protein thermostability is of theoretical and
practical importance. While numerous determinants have been suggested, no molecular …

Next-generation DNA sequencing technologies have revolutionized diverse genomics
applications, including de novo genome sequencing, SNP detection, chromatin …

The Kepler mission is providing photometric data of exquisite quality for the asteroseismic
study of different classes of pulsating stars. These analyses place particular demands on the …