The mechanisms underlying haematopoietic lineage decisions remain disputed. Lineage-affiliated
transcription factors 1 , 2 with the capacity for lineage reprogramming 3 , positive auto-…

Most models of cancer cell population expansion assume exponential growth kinetics at low
cell densities, with deviations to account for observed slowing of growth rate only at higher …

Adult murine neural stem cells (NSCs) generate neurons in drastically declining numbers
with age. How cellular dynamics sustain neurogenesis and how alterations with age may …

Molecular regulation of cell fate decisions underlies health and disease. To identify molecules
that are active or regulated during a decision, and not before or after, the decision time …

Accessing gene expression at a single-cell level has unraveled often large heterogeneity
among seemingly homogeneous cells, which remains obscured when using traditional …

Mitochondrial functions are essential for cell survival. Pathologic situations, eg cancer, can
impair mitochondrial function which is frequently reflected by an altered morphology. So far, …

Background Time-lapse microscopy allows to monitor cell state transitions in a spatiotemporal
context. Combined with single cell tracking and appropriate cell state markers, transition …

Gene set scoring (or enrichment) is a common dimension reduction task in bioinformatics that
can be focused on the differences between groups or at the single sample level. Gene sets …

Motivation: Gene set scoring is a common task in bioinformatics, but the sparsity of data points
in single cell gene expression creates difficulties. Results: By applying matrix smoothing …

Bifunctional active regions, capable of light generation and detection at the same wavelength,
allow a straightforward realization of the integrated mid-infrared photonics for sensing …