The face of evolutionary biology is changing: from reconstructing and analysing the past to
predicting future evolutionary processes. Recent developments include prediction of …

The seasonal human influenza A/H3N2 virus undergoes rapid evolution, which produces
significant year-to-year sequence turnover in the population of circulating strains. Adaptive …

Background The structure of molecular networks derives from dynamical processes on
evolutionary time scales. For protein interaction networks, global statistical features of their …

Natural selection favors fitter variants in a population, but actual evolutionary processes may
decrease fitness by mutations and genetic drift. How is the stochastic evolution of molecular …

Evolution is a quest for innovation. Organisms adapt to changing natural selection by evolving
new phenotypes. Can we read this dynamics in their genomes? Not every mutation under …

Molecular evolution is a stochastic process governed by fitness, mutations, and reproductive
fluctuations in a population. Here, we study evolution where fitness itself is stochastic, with …

Background The regulation of a gene depends on the binding of transcription factors to
specific sites located in the regulatory region of the gene. The generation of these binding sites …

As the first line of defence against pathogens, cells mount an innate immune response,
which varies widely from cell to cell. The response must be potent but carefully controlled to …

We develop a statistical theory of networks. A network is a set of vertices and links given by
its adjacency matrix c, and the relevant statistical ensembles are defined in terms of a …

A fraction of COVID-19 convalescent individuals mount a potent antibody response to SARS-CoV-2
with cross-reactivity to SARS-CoV-1. To uncover their humoral response in detail, we …