User profiles for Michael L. Levy

Michael Levy MD PhD

Professor of Neurosurgery, UCSD
Verified email at rchsd.org
Cited by 37786

[HTML][HTML] Subgroup-specific structural variation across 1,000 medulloblastoma genomes

…, S Robinson, M Zollo, CC Faria, JA Chan, ML Levy… - Nature, 2012 - nature.com
Medulloblastoma, the most common malignant paediatric brain tumour, is currently treated
with nonspecific cytotoxic therapies including surgery, whole-brain radiation, and aggressive …

An environment-dependent transcriptional network specifies human microglia identity

…, MP Pasillas, M Pena, A Adair, DD Gonda, ML Levy… - Science, 2017 - science.org
INTRODUCTION Microglia play essential roles in central nervous system homeostasis and
influence diverse aspects of neuronal function, including refinement of synaptic networks and …

Brain cell type–specific enhancer–promoter interactome maps and disease-risk association

…, JB Brewer, D Gosselin, DD Gonda, ML Levy… - Science, 2019 - science.org
Noncoding genetic variation is a major driver of phenotypic diversity, but functional interpretation
is challenging. To better understand common genetic variation associated with brain …

Pathogenesis and pharmacological strategies for mitigating secondary damage in acute spinal cord injury

AP Amar, ML Levy - Neurosurgery, 1999 - journals.lww.com
OBJECTIVE: Experimental models and clinical observations of acute spinal cord injury (SCI)
support the concepts of primary and secondary injury, in which the initial mechanical insult …

Propofol in the treatment of moderate and severe head injury: a randomized, prospective double-blinded pilot trial

…, ET Chappell, MJ Rosner, J Jacobson, ML Levy… - Journal of …, 1999 - thejns.org
Object. Sedation regimens for head-injured patients are quite variable. The short-acting
sedative—anesthetic agent propofol is being increasingly used in such patients, yet little is …

[PDF][PDF] HDAC and PI3K antagonists cooperate to inhibit growth of MYC-driven medulloblastoma

…, JM Olson, YJ Cho, XN Li, JR Crawford, ML Levy… - Cancer cell, 2016 - cell.com
Medulloblastoma (MB) is a highly malignant pediatric brain tumor. Despite aggressive therapy,
many patients succumb to the disease, and survivors experience severe side effects from …

Temporary occlusion of the middle cerebral artery in intracranial aneurysm surgery: time limitation and advantage of brain protection

SD Lavine, LS Masri, ML Levy, SL Giannotta - Journal of neurosurgery, 1997 - thejns.org
✓ The risk of focal infarction secondary to the induced reversible arrest of local arterial flow
during microsurgical dissection of middle cerebral artery (MCA) aneurysms was evaluated …

Causes, epidemiology, and risk factors of chronic subdural hematoma

JCT Chen, ML Levy - Neurosurgery Clinics, 2000 - neurosurgery.theclinics.com
Chronic subdural hematoma is an important reversible cause of dementia and disability in
the elderly. A sufficiently high level of clinical suspicion and prompt radiographic evaluation …

An institutional experience with cervical vagus nerve trunk stimulation for medically refractory epilepsy: rationale, technique, and outcome

AP Amar, CN Heck, ML Levy, T Smith… - …, 1998 - journals.lww.com
OBJECTIVE: Intermittent stimulation of the left cervical vagus nerve trunk is emerging as a
novel adjunct in the treatment of medically refractory seizures. We sought to evaluate …

Microsurgical keyhole approach for middle fossa arachnoid cyst fenestration

ML Levy, M Wang, HE Aryan, K Yoo, H Meltzer - Neurosurgery, 2003 - journals.lww.com
OBJECTIVE: The optimal surgical treatment for symptomatic temporal arachnoid cysts is
controversial. Therapeutic options include cyst shunting, endoscopic fenestration, and …