Background Transthyretin amyloidosis, also called ATTR amyloidosis, is a life-threatening
disease characterized by progressive accumulation of misfolded transthyretin (TTR) protein in …

Inflammatory processes are prominent in various types of human and experimental pulmonary
hypertension (PH) and are increasingly recognized as major pathogenic components of …

Pulmonary arterial hypertension (PAH) is a lethal syndrome characterized by vascular
obstruction and right ventricular failure. Although the fundamental cause remains elusive, many …

Hypertension is a mechanism-based toxic effect of drugs that inhibit the vascular endothelial
growth factor signaling pathway (VSP). Substantial evidence exists for managing …

Purpose Vorinostat, a histone deacetylase inhibitor, exerts anticancer effects by both histone
and nonhistone–mediated mechanisms. It also enhances the anticancer effects of platinum …

Genetic variation influences the response of an individual to drug treatments. Understanding
this variation has the potential to make therapy safer and more effective by determining …

Purpose: Hypertension is a mechanism-based toxicity of sorafenib and other cancer
therapeutics that inhibit the vascular endothelial growth factor (VEGF) signaling pathway. This …

Background Accurate grading of dermatologic adverse events (AE) due to epidermal growth
factor receptor (EGFR) inhibitors (EGFRIs) is necessary for drug toxicity determinations, …

Purpose The risk of severe neutropenia from treatment with irinotecan is related in part to
UGT1A1* 28, a variant that reduces the elimination of SN-38, the active metabolite of irinotecan…

Background The primary objective of phase II cancer clinical trials is to determine whether a
new regimen has sufficient activity to warrant further study, with activity generally defined as …