DNA can determine where and when genes are expressed, but the full set of sequence
determinants that control gene expression is unknown. Here, we measured the transcriptional …

We present genome-wide occupancy profiles for RNA polymerase (Pol) II, its phosphorylated
forms and transcription factors in proliferating yeast. Pol II exchanges initiation factors for …

Sequencing of newly synthesised RNA can monitor transcriptional dynamics with great
sensitivity and high temporal resolution, but is currently restricted to populations of cells. Here, …

At the end of protein-coding genes, RNA polymerase (Pol) II undergoes a concerted transition
that involves 3′-processing of the pre-mRNA and transcription termination. Here, we …

At active human genes, the +1 nucleosome is located downstream of the RNA polymerase II
(RNA Pol II) pre-initiation complex (PIC). However, at inactive genes, the +1 nucleosome is …

In different phases of the transcription cycle, RNA polymerase (Pol) II recruits various factors
via its C-terminal domain (CTD), which consists of conserved heptapeptide repeats with the …

Enhancer-mediated gene activation generally requires physical proximity between
enhancers and their target gene promoters. However, the molecular mechanisms by which …

The Nrd1-Nab3-Sen1 (NNS) complex is essential for controlling pervasive transcription and
generating sn/snoRNAs in S. cerevisiae. The NNS complex terminates transcription of …

At the 3′ ends of protein-coding genes, RNA polymerase (Pol) II is dephosphorylated at
tyrosine residues (Tyr1) of its C-terminal domain (CTD). In addition, the associated cleavage-…

During viral infections cellular gene expression is subject to rapid alterations induced by
both viral and antiviral mechanisms. In this study, we applied metabolic labeling of newly …