In the cell, DNA is arranged into highly-organised and topologically-constrained (supercoiled)
structures. It remains unclear how this supercoiling affects the detailed double-helical …

Raltegravir shows marked pharmacokinetic variability in patients, with gastrointestinal pH
and divalent-metal binding being potential factors. We investigated raltegravir solubility, …

Small DNA circles can occur in Nature, for example as protein-constrained loops, and can
be synthesized by a number of methods. Such small circles provide tractable systems for the …

SgrAI is a type II restriction endonuclease with an unusual mechanism of activation involving
run-on oligomerization. The run-on oligomer is formed from complexes of SgrAI bound to …

Objective Agarose gel electrophoresis has been the mainstay technique for the analysis of
DNA samples of moderate size. In addition to separating linear DNA molecules, it can also …

Pesticides are known to contain numerous genotoxic compounds; however, genotoxicity
biomonitoring studies of workers occupationally exposed to pesticides have produced variable …

In the present study, the genotoxic effects of commonly applied pesticides were evaluated
using the alkaline comet assay (pH > 13). The amount of DNA damage (% DNA in tail) in …

The effect of 3′-S-phosphorothiolate linkages on the stability of RNA·RNA duplexes and G-quadruplex
structures has been studied. 3′-Thio-2′-deoxyuridine was incorporated into …

In the cell, DNA is arranged into highly-organised and topologically-constrained (supercoiled)
structures. It remains unclear how this supercoiling affects the double-helical structure of …

The synthesis of oligodeoxynucleotides containing 3′-thionucleosides has been explored
using a reverse-direction (5′→3′) approach, based on nucleoside monomers which …