The CCR5-Δ32 deletion obliterates the CCR5 chemokine and the human immunodeficiency
virus (HIV)–1 coreceptor on lymphoid cells, leading to strong resistance against HIV-1 …

Admixture mapping (also known as "mapping by admixture linkage disequilibrium," or MALD)
provides a way of localizing genes that cause disease, in admixed ethnic groups such as …

Most genetic susceptibility to cutaneous melanoma remains to be discovered. Meta-analysis
genome-wide association study (GWAS) of 36,760 cases of melanoma (67% newly …

Nasopharyngeal carcinoma (NPC) is an epithelial malignancy facilitated by Epstein-Barr
Virus infection. Here we resolve the major genetic influences for NPC incidence using a …

Background & Aims Aflatoxin, which causes hepatocellular carcinoma, may also cause
gallbladder cancer. We investigated whether patients with gallbladder cancer have higher …

Purpose Single-cell RNA sequencing (scRNA-seq) is a powerful technique used to explore
gene expression at the single cell level. However, appropriate preparation of samples is …

Background. Host genetic variation influences human immunodeficiency virus (HIV) infection
and progression to AIDS. Here we used clinically well-characterized subjects from 5 …

Familial acute myeloid leukemia is rare and linked to germline mutations in RUNX1, GATA2
or CCAAT/enhancer binding protein-α (CEBPA). We re-evaluated a large family with acute …

Background The human mitochondrial genome includes only 13 coding genes while
nuclear-encoded genes account for 99% of proteins responsible for mitochondrial morphology, …

Background Hoyeraal-Hreidarsson syndrome is a dyskeratosis congenita–related telomere
biology disorder that presents in infancy with intrauterine growth retardation, …