Highly regenerative tissues such as blood must possess effective DNA damage responses (DDR)
that balance long-term regeneration with protection from leukemogenesis. …

Replicative senescence is an irreversible cell cycle arrest that limits the proliferation of
damaged cells and may be an important tumor suppression mechanism in vivo. This process is …

Cancer-associated fibroblasts (CAFs) are highly prominent in breast tumors, but their
functional heterogeneity and origin are still largely unresolved. We report that bone marrow (BM)–…

The cellular function of p53 is complex. It is well known that p53 plays a key role in cellular
response to DNA damage. Moreover, p53 was implicated in cellular senescence, and it was …

Inactivation of p53 and activation of telomerase occur in the majority of human cancers,
raising the possibility of a link between these two pathways. Overexpression of wild-type p53 …

Telomere shortening in primary human fibroblasts results in replicative senescence, which
can be overcome by telomerase (hTERT) overexpression. However, because immortalization …

Hypoxic stress is one of the major selective pressures in the microenvironment of solid tumors,
and overcoming this restriction is essential for tumor progression. One of the key factors …

The p53 tumor suppressor gene plays an important role in both apoptosis and DNA repair
pathways that are pivotal for genomic stability. Here we show that the treatment of cells with …

Src homology 2 domain-containing phosphatase 2 (Shp2), encoded by Ptpn11, is a member
of the nonreceptor protein-tyrosine phosphatase family, and functions in cell survival, …

To elucidate the nature of the cross-talk between the p53 protein and the DNA repair machinery,
we have investigated the relationship between the two throughout the cell cycle. Base …