User profiles for Michael N Hall
 | Michael N. HallBiozentrum, University of Basel Verified email at unibas.ch Cited by 68792 |
[HTML][HTML] TOR signaling in growth and metabolism
The target of rapamycin (TOR) is a conserved Ser/Thr kinase that regulates cell growth and
metabolism in response to environmental cues. Here, highlighting contributions from studies …
metabolism in response to environmental cues. Here, highlighting contributions from studies …
TOR controls translation initiation and early G1 progression in yeast.
Saccharomyces cerevisiae cells treated with the immunosuppressant rapamycin or depleted
for the targets of rapamycin TOR1 and TOR2 arrest growth in the early G1 phase of the cell …
for the targets of rapamycin TOR1 and TOR2 arrest growth in the early G1 phase of the cell …
[PDF][PDF] Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
…, D Bonenfant, W Oppliger, P Jenoe, MN Hall - Molecular cell, 2002 - cell.com
The target of rapamycin (TOR) proteins in Saccharomyces cerevisiae, TOR1 and TOR2,
redundantly regulate growth in a rapamycin-sensitive manner. TOR2 additionally regulates …
redundantly regulate growth in a rapamycin-sensitive manner. TOR2 additionally regulates …
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
…, A Schmidt, S Lin, MA Rüegg, A Hall, MN Hall - Nature cell …, 2004 - nature.com
The target of rapamycin (TOR) is a highly conserved protein kinase and a central controller
of cell growth. In budding yeast, TOR is found in structurally and functionally distinct protein …
of cell growth. In budding yeast, TOR is found in structurally and functionally distinct protein …
[PDF][PDF] TOR, a central controller of cell growth
T Schmelzle, MN Hall - Cell, 2000 - cell.com
Cell growth (increase in cell mass) and cell proliferation (increase in cell number) are distinct
yet coupled processes that go hand-in-hand to give rise to an organ, organism, or tumor. …
yet coupled processes that go hand-in-hand to give rise to an organ, organism, or tumor. …
Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression
…, U Schneider, M Deuter-Reinhard, NR Movva, MN Hall - Cell, 1993 - cell.com
The yeast TOR2 gene encodes an essential 282 kd phosphatidylinositol (PI) 3-kinase
homolog. TOR2 is related to the catalytic subunit of bovine PI 3-kinase and to yeast VPS34, a …
homolog. TOR2 is related to the catalytic subunit of bovine PI 3-kinase and to yeast VPS34, a …
[HTML][HTML] TOR regulates ribosomal protein gene expression via PKA and the Forkhead transcription factor FHL1
The regulation of ribosome biogenesis in response to environmental conditions is a key
aspect of cell growth control. Ribosomal protein (RP) genes are regulated by the nutrient-…
aspect of cell growth control. Ribosomal protein (RP) genes are regulated by the nutrient-…
Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
FK506 and rapamycin are related immunosuppressive compounds that block helper T cell
activation by interfering with signal transduction. In vitro, both drugs bind and inhibit the FK506…
activation by interfering with signal transduction. In vitro, both drugs bind and inhibit the FK506…
The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors
T Beck, MN Hall - Nature, 1999 - nature.com
The rapamycin-sensitive TOR signalling pathway in Saccharomyces cerevisiae activates a
cell-growth program in response to nutrients such as nitrogen and carbon 1 , 2 , 3 , 4 . The …
cell-growth program in response to nutrients such as nitrogen and carbon 1 , 2 , 3 , 4 . The …
Making new contacts: the mTOR network in metabolism and signalling crosstalk
M Shimobayashi, MN Hall - Nature reviews Molecular cell biology, 2014 - nature.com
More than 20 years after its discovery, our understanding of target of rapamycin (TOR)
signalling continues to grow. Recent global 'omics' studies have revealed physiological roles of …
signalling continues to grow. Recent global 'omics' studies have revealed physiological roles of …