Cognition and mood in Parkinson's disease in subthalamic nucleus versus globus pallidus interna deep brain stimulation: the COMPARE trial
Objective Our aim was to compare in a prospective blinded study the cognitive and mood
effects of subthalamic nucleus (STN) vs. globus pallidus interna (GPi) deep brain stimulation (…
effects of subthalamic nucleus (STN) vs. globus pallidus interna (GPi) deep brain stimulation (…
Genome-wide association study reveals genetic risk underlying Parkinson's disease
We performed a genome-wide association study (GWAS) in 1,713 individuals of European
ancestry with Parkinson's disease (PD) and 3,978 controls. After replication in 3,361 cases …
ancestry with Parkinson's disease (PD) and 3,978 controls. After replication in 3,361 cases …
The coronavirus disease 2019 crisis as catalyst for telemedicine for chronic neurological disorders
… of Florida); Dr Okun has also participated as a … Okun’s deep brain stimulation research is
supported by National Institutes of Health grants R01 NR014852 and R01NS096008. Dr Okun …
supported by National Institutes of Health grants R01 NR014852 and R01NS096008. Dr Okun …
Fully integrated silicon probes for high-density recording of neural activity
Sensory, motor and cognitive operations involve the coordinated action of large neuronal
populations across multiple brain regions in both superficial and deep structures 1 , 2 . Existing …
populations across multiple brain regions in both superficial and deep structures 1 , 2 . Existing …
Parkinson's disease
Parkinson's disease is a recognisable clinical syndrome with a range of causes and clinical
presentations. Parkinson's disease represents a fast-growing neurodegenerative condition; …
presentations. Parkinson's disease represents a fast-growing neurodegenerative condition; …
Diagnosis and treatment of Parkinson disease: a review
MJ Armstrong, MS Okun - Jama, 2020 - jamanetwork.com
Importance Parkinson disease is the most common form of parkinsonism, a group of neurological
disorders with Parkinson disease–like movement problems such as rigidity, slowness, …
disorders with Parkinson disease–like movement problems such as rigidity, slowness, …
Neuropixels 2.0: A miniaturized high-density probe for stable, long-term brain recordings
INTRODUCTION Electrode arrays based on complementary metal-oxide semiconductor
silicon fabrication technology, such as Neuropixels probes, have enabled recordings of …
silicon fabrication technology, such as Neuropixels probes, have enabled recordings of …
[HTML][HTML] The emerging evidence of the Parkinson pandemic
Neurological disorders are now the leading source of disability globally, and the fastest growing
neurological disorder in the world is Parkinson disease. From 1990 to 2015, the number …
neurological disorder in the world is Parkinson disease. From 1990 to 2015, the number …
Deep brain stimulation for Parkinson disease: an expert consensus and review of key issues
Objective: To provide recommendations to patients, physicians, and other health care
providers on several issues involving deep brain stimulation (DBS) for Parkinson disease (PD). …
providers on several issues involving deep brain stimulation (DBS) for Parkinson disease (PD). …
Stimulation of the subthalamic nucleus changes the firing pattern of pallidal neurons
T Hashimoto, CM Elder, MS Okun… - Journal of …, 2003 - Soc Neuroscience
To clarify the mechanism underlying improvement of parkinsonian signs by high-frequency
electrical stimulation (HFS) of the subthalamic nucleus (STN), we investigated the effects of …
electrical stimulation (HFS) of the subthalamic nucleus (STN), we investigated the effects of …